{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T10:04:24Z","timestamp":1779530664143,"version":"3.53.1"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Acute myeloid leukemia (AML) harboring\n                      <jats:italic>BCR::ABL1<\/jats:italic>\n                      is considered a separate diagnostic entity and is classified as adverse in the risk score of the European LeukemiaNet. However, its prognosis could change with the addition of tyrosine kinase inhibitors (TKI) to chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, the authors interrogated Programa Espa\u00f1ol de Tratamientos en Hematolog\u00eda (PETHEMA) AML epidemiologic registry to shed light on the outcome of patients with AML harboring\n                      <jats:italic>BCR::ABL1<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010seven patients with newly diagnosed AML harboring\n                      <jats:italic>BCR::ABL1<\/jats:italic>\n                      were included, 40 of them treated intensively. Fifteen patients received TKI and 19 did not receive TKI, median overall survival (mOS) was 15.7 months (95% CI, 3.9\u201327.6 months) and 12.3 months (95% CI, 0.4\u201324.1 months), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.28). Median relapse\u2010free survival was not reached versus 7.6 months (95% CI, 3\u201312.2 months) in patients who did or did not receive TKI (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.029). Age, TKI treatment, allogeneic bone marrow transplantation and date of diagnosis were included in the Cox regression analysis, and no independent prognostic factors for OS were found. Comparison of\u00a0\n                      <jats:italic>BCR::ABL1<\/jats:italic>\n                      AML patients with the intensively treated global PETHEMA AML cohort (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a02107) showed that patients who received a TKI had a median overall survival similar to that of the intermediate\u2011risk group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study shows improved outcomes with the addition of TKI to chemotherapy and supports re\u2010classification of AML patients harboring\n                      <jats:italic>BCR::ABL1<\/jats:italic>\n                      in the intermediate\u2010risk group. Nonetheless, given the small sample size, larger studies are needed to confirm these findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70353","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:09:17Z","timestamp":1775819357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reassessing adverse prognosis of acute myeloid leukemia harboring\n                    <i>BCR::ABL1<\/i>\n                    in the era of tyrosine kinase inhibitors: A real\u2010world analysis from the PETHEMA registry"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-5912","authenticated-orcid":false,"given":"Juan M.","family":"Alonso\u2010Dominguez","sequence":"first","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz IIS\u2010FJD UAM  Madrid 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