{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:14:16Z","timestamp":1788952456220,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Older breast cancer survivors are susceptible to cancer\u2010 and treatment\u2010related losses in physical function that can negatively affect daily living activities, mobility, and independence. Although physical activity can improve physical function, few studies have focused on older survivors or explored interrelationships between physical activity and physical function. Longitudinal bidirectional relationships between physical activity and physical function in breast cancer survivors and noncancer controls aged 60+ years were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Survivors (aged 67\u00a0\u00b1\u00a07 years;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0357) newly diagnosed with nonmetastatic breast cancer (stages 0\u2013III) and noncancer controls (aged 67\u00a0\u00b1\u00a09 years;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0254) were assessed at baseline (postsurgery and pre\u2013systemic therapy among survivors) and annual visits for up to 36 months. Physical activity (steps per day) was assessed via actigraphy. The Timed Up and Go test (longer time\u00a0indicates\u00a0lower function) and 12\u2010item Short Form Health Survey Physical Component Score evaluated physical function. Data were analyzed via random\u2010intercepts cross\u2010lagged panel models, with controlling for covariates;\n                      <jats:italic>p<\/jats:italic>\n                      values of \u02c2.05 were considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Starting from the 12\u2010month visit, higher daily steps predicted better subsequent Timed Up and Go time among survivors and controls, and the magnitude of effect was stronger for survivors than controls at 24 months (post hoc comparison,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.036; survivors: \u03b2\u00a0=\u00a0\u22120.420;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003; controls: \u03b2\u00a0=\u00a0\u22120.211;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.032). Timed Up and Go time did not predict later daily steps. Associations between steps and the Physical Component Score showed similar patterns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher daily steps predicted better subsequent physical function, especially in survivors. These results highlight the importance of promoting physical activity during cancer survivorship care to maintain functional independence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70366","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:25:39Z","timestamp":1781090739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Examining bidirectional longitudinal relationships between physical activity and physical function in older breast cancer survivors: The Thinking and Living with Cancer study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8811-566X","authenticated-orcid":false,"given":"Ashley L.","family":"Artese","sequence":"first","affiliation":[{"name":"Department of Exercise Science and Health Promotion Charles E. 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