{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:01:30Z","timestamp":1775642490461,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Chondrosarcoma (CS) has a prognosis largely influenced by tumor grade. Although\n IDH<\/jats:italic>\n mutations have been reported in CS, impact on patient`s survival remains controversial. This study aims to assess prognostic relevance of\n IDH<\/jats:italic>\n mutations on disease\u2010specific survival (DSS), metastasis\u2010free survival (MFS), and local recurrence\u2010free survival (RFS), in a large cohort of CS patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The authors retrospectively analyzed CS samples from patients treated at two German musculoskeletal tumor centers. Tumor\u2010specific mutations, including\n IDH<\/jats:italic>\n ,\n TP53<\/jats:italic>\n ,\n TERT promoter<\/jats:italic>\n , and\n CDKN2A\/B<\/jats:italic>\n , were identified through DNA isolation and next\u2010sequencing. Molecular findings were correlated with oncologic outcomes to evaluate their prognostic significance.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 109 patients (53 females, 56 males; median age, 57 (16\u201389) years) were included. Tumor grades were G1\/ACT (39%), G2 (41%), and G3\/dedifferentiated (10%). Median follow\u2010up was 3.8 years with mortality of 17%.\n IDH<\/jats:italic>\n mutations were detected in 59% (\n IDH1<\/jats:italic>\n : 64%,\n IDH2<\/jats:italic>\n : 36%), with dedifferentiated CS showing highest\n IDH<\/jats:italic>\n mutation rate (91%), particularly\n IDH2<\/jats:italic>\n .\n IDH2<\/jats:italic>\n \u2010mutations were associated with significantly worse DSS compared to\n IDH<\/jats:italic>\n \u2013wild\u2010type or\n IDH1<\/jats:italic>\n \u2010mutated tumors, independent of tumor grade. Specifically,\n IDH1<\/jats:italic>\n \u2010\n R132C<\/jats:italic>\n mutation correlated with significantly improved DSS compared to\n R132G<\/jats:italic>\n , and\n IDH2<\/jats:italic>\n \u2010\n R172S<\/jats:italic>\n variant showed longest DSS and MFS, whereas\n IDH2<\/jats:italic>\n \u2010\n R172T<\/jats:italic>\n was linked to significant poor outcomes. In multivariable analysis,\n IDH2<\/jats:italic>\n and\n TP53<\/jats:italic>\n mutations were independent predictors of worse survival.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n IDH2<\/jats:italic>\n and\n TP53<\/jats:italic>\n mutations are enriched in dedifferentiated CS and are significant, independent predictors of adverse survival, regardless of tumor grade. These findings support\n IDH2<\/jats:italic>\n mutation status as clinically meaningful prognostic biomarker that may allow risk stratification and clinical decision\u2010making in CS patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cncr.70376","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:56:13Z","timestamp":1774842973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Presence of\n IDH2<\/i>\n and\n TP53<\/i>\n mutations significantly reduces survival of patients with chondrosarcoma"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2698-8120","authenticated-orcid":false,"given":"Anne","family":"Weidlich","sequence":"first","affiliation":[{"name":"University Center for Orthopedics, Trauma Surgery, and Plastic Surgery Sarcoma Center National Center for Tumor Diseases German Cancer Research Center University Hospital Carl Gustav Carus Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2010Dieter","family":"Schaser","sequence":"additional","affiliation":[{"name":"University Center for Orthopedics, Trauma Surgery, and Plastic Surgery Sarcoma Center National Center for Tumor Diseases German Cancer Research Center University Hospital Carl Gustav Carus Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tareq A.","family":"Juratli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurooncology Center National Center for Tumor Diseases German Cancer Research Center University Hospital Carl Gustav Carus Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Pablik","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Carl Gustav Carus Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"M\u00e4rdian","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Surgery Charit\u00e9\u2010Berlin University Medicine Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Hauptmann","sequence":"additional","affiliation":[{"name":"Institute of Pathology Charit\u00e9\u2010Berlin University Medicine Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Schwabe","sequence":"additional","affiliation":[{"name":"Department for Trauma and Orthopedic Surgery, Center for Musculoskeletal Tumor Medicine Vivantes Hospital Spandau Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Richter","sequence":"additional","affiliation":[{"name":"Department of Medicine 1, Sarcoma Center National Center for Tumor Diseases German Cancer Research Center University Hospital Carl Gustav Carus Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagen","family":"Fritzsche","sequence":"additional","affiliation":[{"name":"University Center for Orthopedics, Trauma Surgery, and Plastic Surgery Sarcoma Center National Center for Tumor Diseases German Cancer Research Center University Hospital Carl Gustav Carus Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19950101)75:1+<203::AID\u2010CNCR2820751308>3.0.CO;2\u2010V"},{"key":"e_1_2_10_3_1","volume-title":"Soft Tissue and Bone Tumours","author":"Organisation mondiale de la sant\u00e9, Centre international de recherche sur le 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