{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:26:43Z","timestamp":1777987603102,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Large\u2010scale studies of germline variants in hereditary cancer susceptibility genes among Chinese epithelial ovarian cancer (EOC) patients remain limited. This study assessed the prevalence and clinical significance of germline variants in 21 genes relevant to hereditary breast and ovarian cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter prospective cohort (February 2017\u2013December 2018), 961 unselected EOC patients underwent germline testing for 21 genes. Variant frequencies were compared with international data, and associations with clinicopathologic characteristics and survival outcomes were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pathogenic or likely pathogenic (P\/LP) variants were identified in\n                      <jats:italic>BRCA1<\/jats:italic>\n                      (17.79%),\n                      <jats:italic>BRCA2<\/jats:italic>\n                      (6.35%), and other homologous recombination (HR)\u2010related genes (2.71%). P\/LP variants in non\u2010HR\u2010related genes were rare (0.1%).\n                      <jats:italic>BRCA1<\/jats:italic>\n                      and\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      P\/LP variant carriers were more likely to respond to platinum\u2010based chemotherapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002 and\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Variants of uncertain significance or higher (VUS+) in HR\u2010related genes were associated with better overall survival (hazard ratio, 0.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004) and progression\u2010free survival (hazard ratio, 0.75;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), with a trend more pronounced than that observed for\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      VUS\u00a0+\u00a0carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over 25% of Chinese EOC patients carry germline HR\u2010related gene variants, which are associated with better treatment response and survival. Broad genetic testing is critical, and the prognostic value of VUS warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70395","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:02:46Z","timestamp":1777266166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multigene germline testing for epithelial ovarian cancer in China"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8723-3461","authenticated-orcid":false,"given":"Lei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetric &amp; Gynecologic Diseases  Beijing China"},{"name":"State Key Laboratory for Complex Severe and Rare Diseases Peking Union Medical College Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing) Department of Gynecology Peking University Cancer Hospital &amp; 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