{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:54:33Z","timestamp":1784876073255,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study evaluates baseline inflammatory biomarkers prognostic of clinical outcomes for patients with metastatic castration\u2010resistant prostate cancer (mCRPC) treated with Lutetium\u2010177 (\n                      <jats:sup>177<\/jats:sup>\n                      Lu)\u2013PSMA\u2010617.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective review of patients treated with\n                      <jats:sup>177<\/jats:sup>\n                      Lu\u2013PSMA\u2010617 at Emory Winship Cancer Institute was conducted. Baseline inflammatory markers obtained included neutrophil\u2010to\u2010lymphocyte ratio (NLR), monocyte\u2010to\u2010lymphocyte ratio (MLR), platelet\u2010to\u2010lymphocyte ratio (PLR), systemic immune\u2010inflammation index (SII), pan\u2010immune\u2010inflammation value (PIV), and hemoglobin\u2010to\u2010platelet ratio (HPR). Cox proportional hazards models assessed overall survival (OS) and progression\u2010free survival (PFS), and a logistic regression model assessed \u226550% decline in prostate\u2010specific antigen (PSA) from baseline (PSA50). A prognostic biomarker composite score was generated using best\u2010subset variable selection from a multivariate Cox model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this cohort of 163 patients (median age 73; 51.6% White, 43.6% Black) with mCRPC treated with\n                      <jats:sup>177<\/jats:sup>\n                      Lu\u2013PSMA\u2010617, elevated NLR, PLR, PIV, SII, and reduced HPR were independent prognostic biomarkers of shortened OS (NLR hazard ratio [HR], 2.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002; PLR HR,\u00a02.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.015, PIV HR,\u00a02.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002, SII HR,\u00a02.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003; and HPR HR,\u00a00.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.011). Higher NLR, PLR, and SII values were independently prognostic of shortened PFS (NLR HR,\u00a01.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.012; PLR,\u00a01.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.036; and SII HR,\u00a01.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.009). Patients with elevated HPR and hemoglobin (Hgb) had higher odds of PSA50 response (HPR: 84.8% vs. 15.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.032, median Hgb of PSA50 response: 11.5 vs. 10.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01). The biomarker composite score stratified overall survival with good discrimination (C\u2010index\u00a0=\u00a00.732), demonstrating a reduction in mortality risk from the high\u2010tercile group to intermediate\u2010tercile (HR, 0.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.022) and low\u2010tercile (HR,\u00a00.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Baseline inflammatory markers are associated with clinical outcomes for patients treated with\n                      <jats:sup>177<\/jats:sup>\n                      Lu\u2013PSMA\u2010617.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70410","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:45:07Z","timestamp":1776339907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inflammatory biomarkers have a prognostic role in patients with metastatic castration\u2010resistant prostate cancer treated with Lutetium\u2010177\u2013PSMA\u2010617"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9002-7697","authenticated-orcid":false,"given":"Margo B.","family":"Gerke","sequence":"first","affiliation":[{"name":"Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0004-4027","authenticated-orcid":false,"given":"Angelo","family":"Marra","sequence":"additional","affiliation":[{"name":"Biostatistics Shared Resource Winship Cancer Institute Emory 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