{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:23:09Z","timestamp":1777987389204,"version":"3.51.4"},"reference-count":63,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Squamous cell oropharyngeal cancer (OPC) incidence in men has surpassed cervical cancer in women as the most common cancer linked to high\u2010risk human papillomavirus (HPV). However, vaccine uptake remains suboptimal in both sexes. The objectives of this study were to quantify disability\u2010adjusted life\u2010years (DALYs) because of HPV\u2010associated OPC in US men from 2017 to 2021 and to highlight the potential impact of widespread vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Crude incidence counts and 12\u2010month survival rates were extracted from the National Cancer Institute\u2019s Surveillance, Epidemiology, and End Results SEER 17 database for OPC of the tonsils and tongue base. HPV\u2010attributable cases were estimated by using population\u2010attributable fractions. DALYs were calculated as the sum of years of life lost, years lived with disability among survivors, and years lived with disability among decedents. The annual percent change was used to assess trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2017 to 2021 in US men, average annual DALYs were highest for tonsillar cancers (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a058,979), followed by base of tongue cancers (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040,440). DALYs decreased significantly for cancers of the tonsils (annual percent change, \u22122.44%) and the base of tongue (annual percent change, \u22124.28%). Among adults aged 65 years and older, DALYs increased for both subsites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tonsillar cancers carried the highest DALY burden among HPV\u2010associated OPCs in US men. Patients who were aged 65 years and older and were never vaccine\u2010eligible presented significant DALY increases across all cancer subsites, emphasizing the need for gender\u2010neutral HPV vaccination and catch\u2010up programs for high\u2010risk older men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70412","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:24:58Z","timestamp":1776882298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disability\u2010adjusted life\u2010years from human papillomavirus\u2010related oral cavity and pharynx cancers in US men, 2017\u20132021"],"prefix":"10.1002","volume":"132","author":[{"given":"Harshank V.","family":"Patel","sequence":"first","affiliation":[{"name":"Western Michigan University Homer Stryker MD School of Medicine  Kalamazoo Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9962-8946","authenticated-orcid":false,"given":"Madison C.","family":"Laird","sequence":"additional","affiliation":[{"name":"Western Michigan University Homer Stryker MD School of Medicine  Kalamazoo Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Crone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Summa Health  Akorn Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjasa","family":"Hranjec","sequence":"additional","affiliation":[{"name":"Western Michigan University Homer Stryker MD School of Medicine  Kalamazoo Michigan USA"},{"name":"Department of Trauma Surgery Bronson Methodist Hospital  Kalamazoo Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanita","family":"Motiani","sequence":"additional","affiliation":[{"name":"Western Michigan University Homer Stryker MD School of Medicine  Kalamazoo Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fehmida M.","family":"Laxmidhar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Western Reserve Health Education\/Northeast Ohio Medical University (NEOMED)  Warren Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iman E. 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