{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:46:20Z","timestamp":1782747980140,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>ASXL1<\/jats:italic>\n                      mutations (\n                      <jats:italic>ASXL1<\/jats:italic>\n                      <jats:sup>MUT<\/jats:sup>\n                      ) are common in acute myeloid leukemia (AML) and have historically conferred an adverse prognosis with intensive chemotherapy. Given the increasing use of venetoclax (VEN)\u2010based lower intensity therapy (LIT), the European LeukemiaNet introduced a four\u2010gene genetic risk classifier in 2024 that categorizes\n                      <jats:italic>ASXL1<\/jats:italic>\n                      <jats:sup>MUT<\/jats:sup>\n                      as favorable risk in the absence of\n                      <jats:italic>FLT3<\/jats:italic>\n                      \u2010ITD,\n                      <jats:italic>RAS<\/jats:italic>\n                      , and\n                      <jats:italic>TP53<\/jats:italic>\n                      mutations. However, the prognostic significance of\n                      <jats:italic>ASXL1<\/jats:italic>\n                      <jats:sup>MUT<\/jats:sup>\n                      across different contemporary LIT+VEN backbones remains controversial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis in 554 adults with newly diagnosed AML treated with LIT was conducted, stratified by\n                      <jats:italic>ASXL1<\/jats:italic>\n                      mutation status and treatment backbone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within the European LeukemiaNet 2024 favorable\u2010risk strata,\n                      <jats:italic>ASXL1<\/jats:italic>\n                      <jats:sup>MUT<\/jats:sup>\n                      were associated with lower response rates and inferior overall survival, with outcomes more closely resembling those of intermediate\u2010risk disease. Survival differences were most pronounced in patients treated with cladribine plus low\u2010dose cytarabine and VEN, but inferior outcomes were also observed with hypomethylating agent + VEN\u2010based regimens. On multivariable analyses accounting for age, cytogenetics, co\u2010mutations, treatment backbone, and stem cell transplantation,\n                      <jats:italic>ASXL1<\/jats:italic>\n                      <jats:sup>MUT<\/jats:sup>\n                      remained independently associated with inferior overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Collectively, these findings suggest that\n                      <jats:italic>ASXL1<\/jats:italic>\n                      <jats:sup>MUT<\/jats:sup>\n                      AML may be more appropriately classified as intermediate risk in the context of LIT+VEN\u2013based therapy, with the depth of impact influenced by the specific LIT backbone.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70434","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:05:17Z","timestamp":1778065517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of\n                    <i>ASXL1<\/i>\n                    mutations in acute myeloid leukemia treated with lower intensity therapy"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9595-1279","authenticated-orcid":false,"given":"Jennifer","family":"Marvin\u2010Peek","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-0390","authenticated-orcid":false,"given":"Courtney D.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"Department of Leukemia The 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