{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:40:16Z","timestamp":1792532416306,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Momelotinib, a\n                      <jats:italic>JAK1<\/jats:italic>\n                      \/\n                      <jats:italic>JAK2<\/jats:italic>\n                      \/\n                      <jats:italic>ACVR1<\/jats:italic>\n                      inhibitor, is approved for treating myelofibrosis with splenomegaly, symptoms, and moderate\u2010to\u2010severe anemia. Evidence on its real\u2010world effectiveness after ruxolitinib failure is limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study retrospectively analyzed 221 patients who received momelotinib after ruxolitinib failure by assessing spleen, symptom, and anemia responses, safety, and survival. Logistic regression analyses identified the responses\u2019 predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Before momelotinib initiation, all patients had received ruxolitinib for a median of 31.5 months and discontinued as a result of resistance (29.9%), intolerance (48.0%), or both (22.1%). At baseline, all patients started at full dose; 97.3% presented with cytopenia, 34.8% presented with large splenomegaly, and 43.9% were highly symptomatic. Most patients (74.7%) switched from ruxolitinib stop to momelotinib within 2 months without tapering, whereas 18.1% waited over a year. After a median exposure of 8.2 months, adverse events occurred in 35.7% of patients, which prompted dose reductions or permanent discontinuation in 12.7% and 19.9% of cases, respectively. At 6 months, 30.0% achieved \u226550% spleen length reduction (SR50), with higher responses in those with prior SR50 to ruxolitinib and shorter transition intervals. Symptom and anemia responses occurred in 39.2% and 63.4% of cases, respectively. After a median follow\u2010up of 10.3 months, 11 patients (5.0%) progressed to blast phase, and 37 patients (16.7%) died. Two\u2010year overall and progression\u2010free survival (including death and blast phase transformation) were 60.9% and 59.0%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Momelotinib demonstrated meaningful clinical benefit and acceptable safety in cytopenic patients pretreated with ruxolitinib, which supports its role after ruxolitinib failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70457","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:35:32Z","timestamp":1778603732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical benefit and predictors of response to momelotinib after ruxolitinib failure: A cooperative real\u2010world study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-5668","authenticated-orcid":false,"given":"Francesca","family":"Palandri","sequence":"first","affiliation":[{"name":"Istituto di Ematologia \u201cSer\u00e0gnoli\u201d IRCCS Azienda Ospedaliero\u2013Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Hematology and Transplant Unit Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo  Alessandria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M.","family":"Elli","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia e Unit\u00e0 Trapianto di Midollo Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Isidori","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Center AORMN Hospital  Pesaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Gianesello","sequence":"additional","affiliation":[{"name":"Hematology and Clinical Immunology, Department of Medicine University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sartor","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia \u201cSer\u00e0gnoli\u201d IRCCS Azienda Ospedaliero\u2013Universitaria di Bologna  Bologna Italy"},{"name":"Dipartimento di Scienze Mediche e Chirurgiche Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2714-5109","authenticated-orcid":false,"given":"Novella","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Clinical Medicine and Surgery University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Di Perna","sequence":"additional","affiliation":[{"name":"Hematology Hospital \u201cAndrea Tortora\u201d  Pagani Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Morsia","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Clinical and Molecular Sciences, DISCLIMO Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Gallo","sequence":"additional","affiliation":[{"name":"Divisione Semplice di Ematologia ASL TO4 Ciri\u00e9 Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Itri","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera\u2013Universitaria San Luigi Gonzaga Regione Gonzole  Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Montefusco","sequence":"additional","affiliation":[{"name":"Division of Onco\u2010Hematology ASST Santi Paolo e Carlo  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cris\u00e0","sequence":"additional","affiliation":[{"name":"Candiolo Cancer Institute FPO\u2010IRCCS  Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Biagi","sequence":"additional","affiliation":[{"name":"Department of Hematology Polo Universitario Pontino S. 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