{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:43:45Z","timestamp":1792219425839,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Therapeutic strategies for myelodysplastic syndrome\/myeloproliferative neoplasms (MDS\/MPNs) remain suboptimal. Selinexor, an oral selective inhibitor of exportin 1, represents a mechanism\u2010based therapeutic approach. Preclinical and clinical evidence indicated synergistic antileukemic effects when selinexor was combined with hypomethylating agents or janus kinase inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, single\u2010arm trial was conducted to evaluate selinexor plus either azacitidine (for MDS\u2010dominant features) or ruxolitinib (for MPN\u2010dominant features) in patients with MDS\/MPN. The primary end point was the overall response rate at 6 months, which was assessed according to 2015 International Working Group criteria. Secondary end points included safety, progression, and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty patients were enrolled (four with MDS\u2010dominant features, 16 with MPN\u2010dominant features). The median age was 66 years in the MDS group and 62.5 years in the MPN group. The overall response rate was 60% (12 of 20 patients; 95% confidence interval [CI], 36.1%\u201380.5%) overall, 75% (three of four patients; 95% CI, 31.1%\u201395.4%) in the MDS group, and 56.3% (nine of 16 patients; 95% CI, 33.2%\u201376.9%) in the MPN group. In the MDS group, clinical benefits included improvements in the total symptom score, erythroid response, platelet response, and spleen response (one in each of four patients; 25% for each response). In the MPN group, partial responses occurred in two of 16 patients (12.5%), and partial bone marrow responses occurred in three of 16 (18.8%), with additional benefits including spleen response (five of 16; 31.3%), total symptom score improvement (two of 16; 12.5%), erythroid response (two of 16; 12.5%), and platelet response (one of 16; 6.3%). Adverse events occurred in 14 patients (70%). Three patients experienced grade 3 or greater events, including two disease\u2010related fatalities. After a median follow\u2010up of 6 months (range, 2\u201315 months), one patient's disease transformed to acute myeloid leukemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Selinexor combined with azacitidine or ruxolitinib showed encouraging efficacy with a manageable safety profile in patients with MDS\/MPN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70459","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:13:36Z","timestamp":1781867616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selinexor in combination with azacitidine or ruxolitinib in myelodysplastic\/myeloproliferative neoplasm overlap syndromes: A multicenter prospective study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8754-0388","authenticated-orcid":false,"given":"Xijuan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Science  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Science  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Chinese Academy of Medical Science  Beijing 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