{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:44:11Z","timestamp":1790113451108,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Second\u2010generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR\u2010TKIs) are key first\u2010line therapies for advanced non\u2013small cell lung cancer (NSCLC) with uncommon\n                      <jats:italic>EGFR<\/jats:italic>\n                      mutations, with risk stratification mainly based on\n                      <jats:italic>EGFR<\/jats:italic>\n                      mutation subtypes. Emerging evidence suggests programmed death\u2010ligand 1 (PD\u2010L1) expression may affect EGFR\u2010TKI efficacy. This study compared associations of PD\u2010L1 expression and\n                      <jats:italic>EGFR<\/jats:italic>\n                      mutation subtypes with outcomes in patients receiving first\u2010line second\u2010generation EGFR\u2010TKI monotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This dual\u2010center retrospective real\u2010world study included 215 patients with advanced NSCLC harboring uncommon\n                      <jats:italic>EGFR<\/jats:italic>\n                      mutations. Efficacy was evaluated across mutation subtypes (L861Q, G719X, S768I, other single\u2010site, compound mutations). Stratified analyses by PD\u2010L1 expression were performed, with prognostic value explored in primary lung lesions and metastatic lymph nodes. Primary end points include progression\u2010free survival (PFS), objective response rate (ORR), and disease control rate (DCR).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median PFS for all patients was 14.07 months (ORR,\u00a049.3%; DCR,\u00a089.8%). No statistically significant differences in ORR, DCR, or median PFS were observed among uncommon\n                      <jats:italic>EGFR<\/jats:italic>\n                      mutation subtypes. In contrast, high PD\u2010L1 expression was significantly associated with shorter PFS. Furthermore, PD\u2010L1 expression (tumor proportion score [TPS] \u22651%) in primary lung lesions was associated with shorter PFS, whereas no similar association was observed in metastatic lymph nodes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In advanced NSCLC with uncommon\n                      <jats:italic>EGFR<\/jats:italic>\n                      mutations, first\u2010line second\u2010generation EGFR\u2010TKI monotherapy shows no statistically significant efficacy differences across mutation subtypes. PD\u2010L1 expression is inversely associated with outcomes, with prognostic value differing between primary tumors and metastatic lymph nodes, highlighting the importance of tissue sampling site in risk stratification.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70460","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:18:03Z","timestamp":1778829483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["PD\u2010L1 expression is associated with inferior outcomes independent of\n                    <i>EGFR<\/i>\n                    subtype in advanced non\u2013small cell lung cancer with uncommon\n                    <i>EGFR<\/i>\n                    mutations treated with first\u2010line second\u2010generation EGFR\u2010tyrosine kinase 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