{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:03:00Z","timestamp":1784300580006,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UG1CA189828"],"award-info":[{"award-number":["UG1CA189828"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Black patients with breast cancer experience higher rates of taxane\u2010induced peripheral neuropathy (TIPN), which may compromise chemotherapy dose delivery and health\u2010related quality of life (HRQOL). Using the prospective ECOG\u2010ACRIN EAZ171 trial, the authors examined whether patient\u2010reported TIPN predicts dose reductions and longer\u2010term declines in HRQOL and physical function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EAZ171 enrolled 249 Black patients planned for (neo)adjuvant taxane; 239 with available patient\u2010reported outcome (PRO) data were analyzed. TIPN was assessed during treatment using the Functional Assessment of Cancer Therapy GOG Neurotoxicity scale (FACT\u2010GOG\/NTx) (4\u2010item, 11\u2010item, and single items) and PRO\u2010Common Terminology Criteria for Adverse Events numbness\/tingling and interference. HRQOL (FACT\u2010G) and physical function (PROMIS PF\u201010a) were measured through 12 months. Multivariable mixed\u2010effects logistic models evaluated associations between TIPN, taxane dose reduction due to neuropathy, and 12\u2010month HRQOL or physical function decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All TIPN PROs were associated with dose reduction, with the FACT\u2010GOG\/NTx 4\u2010item subscale showing the strongest association (odds ratio [OR], 10.8; 95% CI, 4.5\u201325.9). Twelve\u2010month PRO data were available for 140 patients (59%). Neuropathy reported during treatment was not associated with reduced HRQOL or physical function at 12 months; however, persistent neuropathy at 12 months was associated with worse HRQOL (OR, 5.05; 95% CI, 1.33\u201319.17) and physical function (OR, 5.29; 95% CI, 1.57\u201017.83).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TIPN was common and strongly predicted taxane dose reduction in Black patients. The FACT\u2010GOG\/NTx 4\u2010item subscale performed best, supporting its use in future trials. Although early TIPN did not predict long\u2010term functional decline, persistent neuropathy adversely affected HRQOL, underscoring the importance of early identification and supportive care to improve dose delivery and equity in breast cancer outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70466","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:14:53Z","timestamp":1780118093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of patient\u2010reported taxane\u2010induced peripheral neuropathy on dose reductions or worsening quality of life in Black women with breast cancer: Analysis from ECOG\u2010ACRIN EAZ171"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-2758","authenticated-orcid":false,"given":"Tarah J.","family":"Ballinger","sequence":"first","affiliation":[{"name":"Indiana University Simon Comprehensive Cancer Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-3703","authenticated-orcid":false,"given":"Fengmin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute ECOG\u2010ACRIN Biostatistics Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Indiana University Simon Comprehensive Cancer Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shen","sequence":"additional","affiliation":[{"name":"Indiana University Simon Comprehensive Cancer Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cella","sequence":"additional","affiliation":[{"name":"Northwestern Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-7881","authenticated-orcid":false,"given":"John D.","family":"Peipert","sequence":"additional","affiliation":[{"name":"University of Birmingham  Edgbaston Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7125-883X","authenticated-orcid":false,"given":"Kathy D.","family":"Miller","sequence":"additional","affiliation":[{"name":"Indiana University Simon Comprehensive Cancer Center  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C.","family":"Wolff","sequence":"additional","affiliation":[{"name":"Johns Hopkins University\/Sidney Kimmel Comprehensive Cancer Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"DeMichele","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia 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