{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:02:59Z","timestamp":1784300579060,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal regimens for older adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) before allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The authors conducted a multicenter phase 2 trial to evaluate the novel venetoclax, fludarabine, and melphalan (VFM) regimen in patients with AML or MDS aged 50 years and older. The VFM regimen consisted of venetoclax (400 mg daily on days \u22128 to \u22122), fludarabine (30 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      daily on days \u22127 to \u2212 3), and melphalan (120\u2013140 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      daily on day \u22122).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty patients (median age, 58 years; age range, 51\u201366 years) received the novel VFM conditioning regimen. The 2\u2010year disease\u2010free survival (DFS) rate was 75.0% (95% confidence interval [CI], 64.8%\u201386.8%), which was the primary end point. Two\u2010year rates of overall survival, graft\u2010versus\u2010host disease (GVHD)\u2013free and recurrence\u2010free survival, nonrelapse mortality, and relapse were 78.3% (95% CI, 68.6%\u201389.5%), 61.6% (95% CI, 50.5%\u201375.3%), 13.3% (95% CI, 6.1%\u201323.3%), and 11.7% (95% CI, 5.1%\u201321.3%), respectively. Treatment\u2010related grade 2\u20133 nonhematologic adverse events occurred in 58% of patients, with no grade 4\u20135 nonhematologic toxicities. The cumulative incidence of grade 2\u20134 and grade 3\u20134 acute GVHD at day 100 was 5.0% (95% CI, 1.3%\u201312.7%) and 1.7% (95% CI, 0.1%\u20137.9%), respectively. The 2\u2010year cumulative incidence of moderate\u2010to\u2010severe chronic GVHD was 16.7% (95% CI, 8.5%\u201327.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support the feasibility of incorporating venetoclax into a fludarabine and melphalan conditioning regimen in older adults with AML\/MDS. Notably, the low rates of GVHD and relapse associated with this venetoclax\u2010based conditioning regimen support further study of this platform [ClinicalTrials.gov Identifier: NCT05084027].<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70467","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:48:38Z","timestamp":1779274118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integration of venetoclax into a fludarabine and melphalan conditioning regimen in patients aged 50 years and older with acute myeloid leukemia and myelodysplastic syndrome: Results from a phase 2 clinical trial"],"prefix":"10.1002","volume":"132","author":[{"given":"Xiaoyu","family":"Lai","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center of The First Affiliated Hospital and Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang 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