{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:44:13Z","timestamp":1790113453784,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The treatment landscape for metastatic non\u2013small cell lung cancer (NSCLC) with\n                      <jats:italic>EGFR exon 20 insertion<\/jats:italic>\n                      (\n                      <jats:italic>ex20ins<\/jats:italic>\n                      ) is rapidly evolving, with the development of specific targeted therapies. The bispecific antibody amivantamab is the new standard of care for this population but real\u2010world safety and efficacy data are lacking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a multicenter, retrospective, observational study conducted on advanced NSCLC patients harboring\n                      <jats:italic>EGFRex20ins<\/jats:italic>\n                      who were included within the ATLAS Italian real\u2010world registry between January and December 2024. Clinical\u2010pathological features, treatment effectiveness, and safety outcomes were retrospectively collected and analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 119 advanced NSCLC patients harboring\n                      <jats:italic>EGFRex20ins<\/jats:italic>\n                      mutations were included. Seventy\u2010six (63.9%) and 24 (20.2%) received first\u2010line platinum\u2010based chemotherapy with or without immunotherapy, respectively. Overall 64 of 119 patients received single agent amivantamab in the subsequent lines. Treatment\u2010related adverse events (TRAEs) of any grade and grade 3\u20134 were reported in 68.8% and 10.9%, respectively, including skin rash (56%, G3 9.4%), asthenia (9%), peripheral edema (8%), and infusion\u2010related reactions (9.4%, G3 1.5%). Dose interruptions, reductions, and discontinuations due to TRAEs occurred in 20.3%, 12.5%, and 3.1% patients, respectively. The objective response rate was 37.5%, the DCR was 66.2%, the median progression\u2010free survival (mPFS) was 9.6 months, and the median overall survival was 16.9 months under amivantamab. Among the 23 patients with brain metastasis, 13% achieved a partial intracranial (ic) response and 43.5% a stable disease. The ic mPFS was 11.6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This data confirms the efficacy and safety profile of amivantamab observed in the CHRYSALIS trial, showing a meaningful clinical benefit in a heavily pretreated real\u2010world population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70476","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:24:21Z","timestamp":1780118661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Amivantamab in advanced non\u2013small cell lung cancer with epidermal growth factor receptor exon 20 insertion mutations: Real\u2010world data from the Italian ATLAS Registry"],"prefix":"10.1002","volume":"132","author":[{"given":"Francesco","family":"Passiglia","sequence":"first","affiliation":[{"name":"Department of Oncology University of Turin S. Luigi Hospital  Orbassano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7575-3870","authenticated-orcid":false,"given":"Antonio","family":"Passaro","sequence":"additional","affiliation":[{"name":"Division of Thoracic Oncology European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Gariazzo","sequence":"additional","affiliation":[{"name":"Medical Oncology Santa Maria Della Misericordia Hospital Azienda Ospedaliera di Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Montrone","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Unit IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pasello","sequence":"additional","affiliation":[{"name":"Department of Surgery Oncology and Gastroenterology University of Padova  Padua Italy"},{"name":"Medical Oncology 2 Istituto Oncologico Veneto IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Tiseo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Parma  Parma Italy"},{"name":"Medical Oncology Unit University Hospital of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Russano","sequence":"additional","affiliation":[{"name":"Medical Oncology Fondazione Policlinico Universitario Campus Bio\u2010Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Citarella","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Istituto Romagnolo per lo Studio dei Tumori \u201cDino Amadori\u201d (IRST) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Anna","family":"Muscarella","sequence":"additional","affiliation":[{"name":"Laboratory of Oncology Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Pozzessere","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Nuovo Ospedale di Prato\u2010Santo Stefano Azienda USL Toscana Centro  Prato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-704X","authenticated-orcid":false,"given":"Emilio","family":"Bria","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore Ospedale Isola Tiberina\u2010Gemelli Isola  Rome Italy"},{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Roca","sequence":"additional","affiliation":[{"name":"Oncologia Toracica\u2010Lung Unit Ospedale P. 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