{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:03:02Z","timestamp":1784300582306,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This trial evaluates the efficacy and safety of combining envafolimab and recombinant human endostatin (Rh\u2010endostatin) in advanced non\u2013small cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This trial included treatment\u2010naive advanced patients with NSCLC with programmed death\u2010ligand 1 (PD\u2010L1)\u2013positive and no driver gene mutations. All patients received treatment with envafolimab and Rh\u2010endostatin every 21 days until disease progression or intolerable toxicity. The primary end points were objective response rate (ORR) and safety. Secondary end points included progression\u2010free survival (PFS), overall survival (OS), disease control rate (DCR), and duration of response (DOR). An exploratory analysis was conducted to identify biomarkers associated with treatment efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 33 patients were included for efficacy and safety analysis. The ORR was 48.5% (95% CI, 30.8%\u201366.5%), and the DCR was 81.8% (95% CI, 64.5%\u201393.0%). The median PFS was 12.3 months (95% CI, 3.1 months\u201321.5 months). With a median follow\u2010up of 13.9 months, the median OS was not reached, and the 1\u2010year OS rate was 73.9%. Treatment\u2010related adverse events (TRAEs) were observed in 25 (75.8%) patients. Grade \u22653 TRAEs were observed in six patients, and there were no grade 4 or 5 AEs. Based on plasma proteomic analysis, receiver operator characteristic analysis yielded area under the curve (AUC) values of 0.77\u00a0(95% CI, 0.61\u20130.93) for MMP1 and 0.68 (95% CI, 0.49\u20130.87) for TNFRSF6B. The combined model demonstrated an AUC of 0.81 (95% CI, 0.66\u20130.96).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Envafolimab combined with Rh\u2010endostatin demonstrated favorable efficacy and tolerable toxicity in patients with PD\u2010L1\u2013positive, advanced driver\u2010gene negative NSCLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70479","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:21:34Z","timestamp":1780122094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First\u2010line envafolimab plus recombinant human\u2010endostatin in\u00a0advanced non\u2013small cell lung cancer with PD\u2010L1 tumor proportion score \u22651% (Endouble): A multicenter, prospective, single\u2010arm, phase 2 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