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Genomic DNA was extracted from formalin\u2010fixed paraffin\u2010embedded tumor tissue samples. Droplet digital polymerase chain reaction was used to assess the prevalence of\n Fn<\/jats:italic>\n . The authors fit logistic regression models for the association between\n Fn<\/jats:italic>\n positivity and CRC\u2010specific mortality, adjusting for age, year of diagnosis, sex, stage, tumor site, population group, and tumor macrodissection status.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Presence of\n Fn<\/jats:italic>\n in CRC tumor tissue was associated with 79% greater odds (95% CI, 1.20\u20132.67) of CRC\u2010specific mortality. This association was more pronounced in participants with rectal (odds ratio [OR], 7.73; 95% CI, 2.13\u201334.79) than proximal colon (OR, 1.17; 95% CI, 0.65\u20132.08) or distal colon tumors (OR, 1.51; 95% CI, 0.74\u20133.04,\n p<\/jats:italic>\n value for interaction\u00a0=\u00a0.023), and more pronounced with respect to early\u2010onset (age <50 years; OR, 10.30; 95% CI, 2.09\u201370.53) than later\u2010onset CRC (age \u226550 years; OR, 1.51; 95% CI, 0.98\u20132.33,\n p<\/jats:italic>\n value for interaction\u00a0= .010).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These findings support an association between presence of\n Fn<\/jats:italic>\n in CRC tumor tissue and CRC\u2010specific mortality, particularly for rectal tumors and early\u2010onset CRC, in a heterogeneous population.\n <\/jats:p>\n 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