{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:43:42Z","timestamp":1792219422831,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1 CA186689"],"award-info":[{"award-number":["UM1 CA186689"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1 CA186709"],"award-info":[{"award-number":["UM1 CA186709"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2P30 CA02100"],"award-info":[{"award-number":["2P30 CA02100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","award":["YIA2025"],"award-info":[{"award-number":["YIA2025"]}],"id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The combination of olaparib plus radium\u2010223 improved progression\u2010free survival in patients with metastatic castration\u2010resistant prostate cancer with bone metastases (BM) in the multicenter, randomized, phase 2 COMRADE trial (NCT03317391). Here, the patient\u2010reported outcome (PRO) analysis of this trial is reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were randomized 1:1 to olaparib plus radium\u2010223 (arm A) or radium\u2010223 alone (arm B). PROs were assessed via the Functional Assessment of Cancer Therapy\u2013Prostate (FACT\u2010P) and Brief Pain Inventory (BPI) at baseline and every 12 weeks. Clinically meaningful changes were defined as a \u226510\u2010point change in FACT\u2010P total score and a \u226530% or \u22652\u2010point change in BPI score. Mixed\u2010effects analysis\u2010of\u2010covariance models assessed PRO changes with adjustment for baseline characteristics among patients with baseline and \u22651 postbaseline assessment within 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 114 treated patients, 74 (65%) were evaluable (arm A,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040; arm B,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a034). Baseline characteristics were balanced, with a median age of 70\u201372 years and Eastern Cooperative Oncology Group performance status of 1 in 60%\u201362%, prior docetaxel in 50%\u201355%, &gt;20 BM in 45%\u201347%, and pain medication use in 60%\u201372% of patients. No significant differences in FACT\u2010P total score change was observed at Week 12 (\u22124.87; 95% CI, \u221213.4 to 3.62) or Week 24 (1.79; 95% CI, \u22128.28 to 11.9). BPI pain severity did not differ at Week 12 (0.44; 95% CI, \u22120.44 to 1.33) or Week 24 (\u22120.20; 95% CI, \u22121.32 to 0.93). Arm B showed greater improvement in BPI pain interference at Week 12 (1.09; 95% CI, 0.14 to 2.05), which was not sustained at Week 24.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The addition of olaparib to radium\u2010223 was not associated with significant detriment to PROs or pain, which supports the tolerability of this combination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70496","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:22:52Z","timestamp":1781871772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient\u2010reported outcomes in castration\u2010resistant prostate cancer with bone metastases treated with radium\u2010223 with or without olaparib"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-7963","authenticated-orcid":false,"given":"Rana R.","family":"McKay","sequence":"first","affiliation":[{"name":"Division of Medical Oncology Department of Medicine University of California San Diego  La Jolla California USA"},{"name":"Department of Urology University of California San Diego  La Jolla California USA"},{"name":"Department of Radiation Medicine and Applied Sciences University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanling","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Data Science Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Ajmera","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Araneta","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Folefac","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland Greenebaum Comprehensive Cancer Center  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos E.","family":"Kyriakopoulos","sequence":"additional","affiliation":[{"name":"Division of Hematology, Medical Oncology, and Palliative Care Department of Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Internal Medicine University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biren","family":"Saraiya","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Department of Medicine Rutgers Robert Wood 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