{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:43:45Z","timestamp":1792219425200,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330085"],"award-info":[{"award-number":["82330085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Patients with unmethylated O\n                      <jats:sup>6<\/jats:sup>\n                      \u2010methylguanine\u2013DNA methyltransferase (\n                      <jats:italic>MGMT<\/jats:italic>\n                      ) glioblastoma derive minimal benefit from the standard temozolomide chemoradiotherapy, leaving an urgent need for more effective therapies. The objective of this phase 2 study was to evaluate the efficacy of anlotinib plus radiotherapy in this disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010arm, phase 2 study, patients with newly diagnosed, unmethylated\n                      <jats:italic>MGMT<\/jats:italic>\n                      glioblastoma were recruited after surgical resection. Patients received standard radiotherapy (60.0 grays) and concomitant with anlotinib (12 mg once daily, 2 weeks on\/1 week off), followed by six cycles of anlotinib maintenance. The primary end point was overall survival (OS). Secondary end points were progression\u2010free survival (PFS), OS rates at 12 and 24 months, PFS rates at 6 and 12 months, and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between October 12, 2020, and August 1, 2022, 32 patients were enrolled and received protocol therapy, and all were evaluable for efficacy and safety analyses. At a median follow\u2010up of 18.6 months (range, 8.3\u201350.3 months), the median OS was 19.1 months (95% confidence interval, 14.4\u201322.4 months), with 12\u2010month and 24\u2010month OS rates of 90.6% and 30.0%, respectively. The median OS did not reach the prespecified threshold of 20.1 months. The median PFS was 11.1 months (95% confidence interval, 9.6\u201312.9 months), with 6\u2010month and 12\u2010month PFS rates of 96.9% and 37.5%, respectively. Four patients (12.5%) experienced grade 3 or worse treatment\u2010related adverse events, two of which (6.3%) were serious. No treatment\u2010related deaths occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Postoperative anlotinib plus radiotherapy demonstrated clinically meaningful activity with a manageable safety profile in patients with unmethylated\n                      <jats:italic>MGMT<\/jats:italic>\n                      glioblastoma (Chinese Clinical Trials Registry identifier: ChiCTR2000040116).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70502","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:34:21Z","timestamp":1782297261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative anlotinib plus radiotherapy in patients with newly diagnosed, unmethylated O\n                    <sup>6<\/sup>\n                    \u2010methylguanine\u2013DNA methyltransferase glioblastoma: A single\u2010arm, phase 2 study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4024-4291","authenticated-orcid":false,"given":"Bian","family":"Wu","sequence":"first","affiliation":[{"name":"Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Key Laboratory of Precision Radiation Oncology  Wuhan China"},{"name":"Institute of Radiation Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Key Laboratory of Precision Radiation Oncology  Wuhan China"},{"name":"Institute of Radiation 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