{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:15:24Z","timestamp":1788952524146,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Up to 30% of women with breast cancer experience cancer\u2010related cognitive impairment (CRCI) even before they receive treatment. The authors conducted a post hoc analysis to examine the relationship between neighborhood socioeconomic disadvantage and CRCI in treatment\u2010naive postmenopausal women with early stage breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The Exercise Program in Cancer and Cognition was a single\u2010blind, 6\u2010month, randomized controlled trial evaluating moderate\u2010intensity aerobic exercise versus usual activity on neurocognitive function. By using baseline data from treatment\u2010naive participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0100), neighborhood socioeconomic disadvantage was assessed using the Area Deprivation Index (national percentile). Cognitive function was measured using composite domain scores. Associations were examined using correlation and linear regression analyses, adjusting for potential covariates\/confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      On average, participants were aged 63 years and had 16 years of education. Greater neighborhood disadvantage was associated with poorer cognitive function in domains of verbal memory (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.032), working memory (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.043), mental flexibility (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.049), and processing speed (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.026). In adjusted analyses, working memory remained associated with the Area Deprivation Index (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.019) with adjustment for age; however, associations with the Area Deprivation Index\u00a0were attenuated for verbal memory after adjustment for education (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.067), for mental flexibility after adjustment for depressive symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= .175), and for processing speed after adjustment for age and body mass index (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.065).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neighborhood socioeconomic disadvantage may contribute to cognitive vulnerability before cancer treatment. However, these findings suggest that years of education and depressive symptoms should be factored into the consideration of neighborhood\u2010level factors when assessing CRCI risk among women with breast cancer (Clinicaltrials.gov identifier NCT02793921).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70506","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:25:27Z","timestamp":1783585527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship of neighborhood socioeconomic disadvantage and pretreatment cancer\u2010related cognitive impairment in women with breast cancer: A post hoc analysis of a randomized controlled trial"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3200-7931","authenticated-orcid":false,"given":"Amanda L.","family":"Gentry","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania USA"},{"name":"University of North Carolina at Chapel Hill School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Sereika","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania USA"},{"name":"University of Pittsburgh Graduate School of Public Health  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk I.","family":"Erickson","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Department of Psychology  Pittsburgh Pennsylvania USA"},{"name":"AdventHealth  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-6793","authenticated-orcid":false,"given":"Maura K.","family":"McCall","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Belcher","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith C.","family":"Cummings","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-2200","authenticated-orcid":false,"given":"Myeong\u2010ga","family":"Cho","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3913-8871","authenticated-orcid":false,"given":"Eliza","family":"Brufsky","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-9673","authenticated-orcid":false,"given":"Margaret Q.","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-9950","authenticated-orcid":false,"given":"Catherine M.","family":"Bender","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Healthy People 2030. 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