{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:11:42Z","timestamp":1788588702291,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gynecologic malignancies\u2014including cervical, endometrial, ovarian, vaginal, and vulvar cancers\u2014represent a major and largely preventable source of mortality in low\u2010 and middle\u2010income countries (LMICs). In 2022, an estimated 1.47 million new cases and over 680,000 deaths were reported globally, with mortality disproportionately concentrated in resource\u2010constrained settings. The survival gap between LMICs and high\u2010income countries (HICs) remains profound, reflecting systemic policy and health system failures in prevention, early detection, and access to treatment. This narrative review synthesizes evidence from PubMed\/MEDLINE, Embase, Cochrane Library, and World Health Organization (WHO) databases, prioritizing literature published between January 2015 and December 2024, with a focus on epidemiology, health system constraints, and policy\u2010relevant interventions. LMICs account for approximately 94% of global cervical cancer deaths, with the highest mortality observed in East Africa (age\u2010standardized mortality rate 35.3 per 100,000). Persistent survival disparities are driven by late\u2010stage diagnosis, limited screening coverage, inadequate radiotherapy infrastructure, workforce shortages, and restricted access to essential and novel therapies. However, evidence demonstrates that cost\u2010effective and scalable interventions\u2014including single\u2010dose human papillomavirus (HPV) vaccination, screen\u2010and\u2010treat strategies, HPV self\u2010sampling, task\u2010shifting models, and international training partnerships\u2014can substantially improve outcomes when embedded within national cancer control policies and supported by sustainable financing mechanisms. Reducing these inequities requires policy\u2010driven, system\u2010level reforms that prioritize prevention, strengthen service delivery, and expand equitable access to care, aligning national strategies with global frameworks such as the WHO 90\u201370\u201390 targets to achieve sustainable cancer control in LMICs.<\/jats:p>","DOI":"10.1002\/cncr.70518","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:01:41Z","timestamp":1787554901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gynecologic cancers in low\u2010 and middle\u2010income countries: Bridging the survival gap"],"prefix":"10.1002","volume":"132","author":[{"given":"Dewi","family":"Setiawati","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences UIN Alauddin Makassar  Gowa Regency South Sulawesi Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wachyudi","family":"Muchsin","sequence":"additional","affiliation":[{"name":"Midwifery Study Program Universitas Islam Makassar  Makassar City South Sulawesi Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-2110","authenticated-orcid":false,"given":"Alfi","family":"Sophan","sequence":"additional","affiliation":[{"name":"The Indonesian Food and Drug Authority  Jakarta Pusat Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.14.04155"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(22)00501\u20100"},{"key":"e_1_2_10_4_1","unstructured":"World Economic Forum.Cervical cancer: How to bridge the health gap. 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GLOBOCAN 2022.2022. Accessed February 2025.https:\/\/gco.iarc.fr\/today"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2024.03.022"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2025.36.e21"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2025.101612"},{"key":"e_1_2_10_18_1","volume-title":"The Every Woman Study Low\u2010 and Middle\u2010Income Countries Edition: initial findings","author":"World Ovarian Cancer Coalition and International Gynecologic Cancer Society","year":"2026"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.65555"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17071145"},{"key":"e_1_2_10_21_1","unstructured":"World Health Organization.Wave of new commitments marks historic step towards the elimination of cervical cancer.2024. 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