{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:53:48Z","timestamp":1792000428196,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer and stroke are major causes of morbidity and mortality, with an increasing shared burden. This study aimed to provide population\u2010based estimates of ischemic stroke (IS) risk after cancer diagnosis across multiple cancer sites and demographic subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted linking the Israel National Cancer and Stroke Registries. Residents \u226540 years old diagnosed with first invasive cancer during 2014\u20132021 were followed for first\u2010ever IS within 1 year. IS risk was assessed using standardized incidence ratios (SIRs) and analyzed by cancer site, time since diagnosis, cancer stage, and demographic subgroups. One\u2010year cumulative incidence was estimated with death as a competing event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 182,221 patients, the SIR for IS within 1 year after cancer diagnosis was 1.8 (95% confidence interval [CI], 1.7\u20131.9). Risk peaked during the first 3\u00a0months (SIR, 2.5; 95% CI, 2.2\u20132.7). The highest SIRs were observed for pancreatic (SIR, 5.9; 95% CI, 4.8\u20137.3) and lung (SIR, 3.9; 95% CI, 3.4\u20134.4) cancers. SIRs decreased with age from 3.6 (95% CI, 2.8\u20134.6) among adults 40\u201354 years old to 1.4 (95% CI, 1.3\u20131.6) among those \u226575 years old. SIRs increased with stage, from 1.2 (95% CI, 1.0\u20131.4) in localized disease to 2.8 (95% CI, 2.5\u20133.2) in metastatic disease. One\u2010year cumulative incidence of IS was 0.62%, ranging from 0.30% in breast cancer to 1.62% in pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The early period after cancer diagnosis represents a critical window of increased IS risk. Incorporating targeted cerebrovascular risk assessment into oncologic care may facilitate earlier identification of high\u2010risk subgroups and support tailored prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70536","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:01:37Z","timestamp":1788850897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Elevated risk of ischemic stroke after invasive cancer diagnosis: A nationwide population\u2010based study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-3446","authenticated-orcid":false,"given":"Carmit","family":"Libruder","sequence":"first","affiliation":[{"name":"School of Public Health University of Haifa  Haifa Israel"},{"name":"Israel Center for Disease Control Israel Ministry of Health  Ramat Gan 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