{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:55:48Z","timestamp":1785862548378,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loncastuximab tesirine, a CD19\u2010directed antibody\u2013drug conjugate, is a therapy for relapsed\/refractory diffuse large B\u2010cell lymphoma (DLBCL), including after chimeric antigen receptor T\u2010cell therapy. This study summarized efficacy and safety across published cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors did a systematic review and meta\u2010analysis of loncastuximab tesirine monotherapy in adults with relapsed or refractory DLBCL. They searched PubMed, Embase, and the Cochrane Library from inception to October 25, 2025,\u00a0plus American Society of Hematology 2025 abstracts. They pooled single\u2010arm proportions using random\u2010effects proportional meta\u2010analyses with Freeman\u2013Tukey transformation and reconstructed individual patient data from Kaplan\u2013Meier curves for time\u2010to\u2010event pooling (protocol: PROSPERO CRD420251156779). Seven studies (596 patients) met inclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven studies (596 patients) contributed to clinical outcomes across all analyses. Pooled overall response was 45.76% (95% CI, 28.75\u201363.28;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a094.3%), and the complete response was 18.83% (95% CI, 10.60\u201328.70,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a085.5%). Reconstructed data yielded a pooled median progression\u2010free survival of 5.18 months (95% CI, 3.97\u20136.15) and median overall survival was 9.01 months (95% CI, 7.60\u201310.73; four studies). Among responders, median duration of response was 10.22 months (95% CI, 6.37\u2013not estimable). Grade \u22653 thrombocytopenia, neutropenia and anemia occurred in 23.71%, 18.80%, and 11.01% of patients, respectively, and treatment discontinuation due to adverse events occurred in 12.61% (95% CI, 5.85\u201321.18).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Loncastuximab tesirine shows clinically meaningful activity in heavily pretreated R\/R DLBCL, including post\u2013CAR T\u2010cell therapy settings, with frequent but manageable cytopenias. Pooled estimates showed substantial heterogeneity, driven mainly by real\u2010world cohorts, and should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70543","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:52:36Z","timestamp":1784789556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of loncastuximab tesirine in heavily pretreated patients with diffuse large B\u2010cell lymphoma, including the post\u2010CAR T\u2010cell therapy setting: A meta\u2010analysis"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3509-3925","authenticated-orcid":false,"given":"Fernando","family":"Gibran\u2010Nunes","sequence":"first","affiliation":[{"name":"Advanced Therapies and Clinical Research Center Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"},{"name":"Department of Hematology, BMT 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Hematology, BMT and Cell Therapy Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Seiwald","sequence":"additional","affiliation":[{"name":"Department of Hematology, BMT and Cell Therapy Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Xue","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Cortez","sequence":"additional","affiliation":[{"name":"Advanced Therapies and Clinical Research Center Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo Brazil"},{"name":"Department of Hematology, BMT and Cell Therapy Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo 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Version 2.2025;2025. Accessed January 12 2026.https:\/\/www.nccn.org\/professionals\/physician_gls\/"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016945"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006245"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014663"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201010\u2010813493"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(21)00139\u2010X"},{"key":"e_1_2_9_13_1","unstructured":"US Food and Drug Administration.FDA grants accelerated approval to loncastuximab tesirine\u2010lpyl for large B\u2010cell lymphoma.2021. 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