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The role of asparaginase in this new landscape of acute lymphoblastic leukemia treatment was extensively discussed by an expert panel of hemato\u2010oncologists to reach a consensus on the safety and efficacy of asparaginase in diverse settings with and without blinatumomab. Herein, the following consensus topics are presented: (1) optimal dosing of asparaginase and therapeutic drug monitoring; (2) prevention of asparaginase hypersensitivity reactions and inactivation; (3) integration of frontline blinatumomab, asparaginase, and antimetabolites; and (4) special issues of asparaginase formulations and adaptations for resource\u2010limited settings.<\/jats:p>","DOI":"10.1002\/cncr.70559","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:01:36Z","timestamp":1786456896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing safety and efficacy of asparaginase and\u00a0blinatumomab therapy in frontline acute lymphoblastic\u00a0leukemia regimens in diverse health care settings\u2014international expert 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