{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:11:56Z","timestamp":1788588716191,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the colony\u2010stimulating factor 1 (\n                      <jats:italic>CSF1<\/jats:italic>\n                      ) gene. Patients report substantial pain, stiffness, and declining physical function; those whose disease is not amenable to surgery require systemic therapy. Vimseltinib is an oral, switch\u2010control kinase inhibitor of the CSF1 receptor (CSF1R). Here, the authors report safety and efficacy of vimseltinib in patients with TGCT based on prior treatment. Cohort A included patients who did not receive prior specific anti\u2010CSF1\/CSF1R agents (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a046; prior imatinib\/nilotinib allowed), and cohort B included patients who received prior specific agents (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The phase 2 (expansion) portion of this ongoing, multicenter, open\u2010label, phase 1\/2 study (NCT03069469) enrolled adults (\u226518 years) with histologically\u2010confirmed TGCT not amenable to surgery. Patients received vimseltinib 30 mg twice weekly (recommended phase 2 dose). The primary objectives were to assess safety and antitumor activity; secondary objectives included assessment of active range of motion (ROM) and patient\u2010reported outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most treatment\u2010emergent adverse events were grade 1\/2, and there was no evidence of cholestatic hepatotoxicity or drug\u2010induced liver injury. Best overall response rates were 64% (29 of 45) and 37% (7 of 19) for cohorts A and B after mean follow\u2010up of 23 and 19 months, respectively. Most patients experienced meaningful improvements in active ROM and patient\u2010reported physical function, stiffness, health status, and pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vimseltinib had a manageable safety profile, demonstrated durable antitumor activity, and provided functional and symptomatic improvements in patients with TGCT, offering an effective treatment option regardless of previous treatment with anti\u2010CSF1\/CSF1R agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70564","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:47:24Z","timestamp":1787726844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vimseltinib for patients with tenosynovial giant cell tumor: A multicenter, open\u2010label, phase 2 trial"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1742-8666","authenticated-orcid":false,"given":"Silvia","family":"Stacchiotti","sequence":"first","affiliation":[{"name":"Fondazione IRCCS Instituto Nazionale dei Tumori  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-120X","authenticated-orcid":false,"given":"Jean\u2010Yves","family":"Blay","sequence":"additional","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-8636","authenticated-orcid":false,"given":"Hans","family":"Gelderblom","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4531-5877","authenticated-orcid":false,"given":"Alejandro","family":"Falc\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen del Roc\u00edo Sevilla  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Le Cesne","sequence":"additional","affiliation":[{"name":"Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayesh","family":"Desai","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Palmerini","sequence":"additional","affiliation":[{"name":"IRCCS Instituto Ortopedico Rizzoli  Bologna Italy"},{"name":"Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1416-8739","authenticated-orcid":false,"given":"C\u00e9sar","family":"Serrano","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen N.","family":"Ganjoo","sequence":"additional","affiliation":[{"name":"Stanford Comprehensive Cancer Center  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina Z.","family":"D\u2019Amato","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Ryan","sequence":"additional","affiliation":[{"name":"OHSU Knight Cancer Institute  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breelyn A.","family":"Wilky","sequence":"additional","affiliation":[{"name":"University of Colorado Cancer Center  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Ferraresi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Nazionale Tumori Regina Elena  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy","family":"Saleh","sequence":"additional","affiliation":[{"name":"McGill University Health Centre Research Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6080-9336","authenticated-orcid":false,"given":"Vinod","family":"Ravi","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albiruni Abdul","family":"Razak","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Casado","family":"Herr\u00e1ez","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahbubl","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Bernthal","sequence":"additional","affiliation":[{"name":"University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-7656","authenticated-orcid":false,"given":"Michiel","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden 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