{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:40:13Z","timestamp":1791567613240,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sexual dysfunction (SD) is an underrecognized late effect of childhood cancer. This study sought to comprehensively examine factors influencing the perceived risk of SD among male survivors of childhood cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult male survivors (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a01581) from the Childhood Cancer Survivor Study who were aged a median of 8 years (range, 0\u201320 years) at cancer diagnosis\u00a0and 38 years (range, 22\u201360 years) at survey reported their perceptions of relative risk for SD compared to peers. Multivariable logistic regression evaluated sociodemographic, treatment, and health factors associated with perceptions of risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 29% of survivors (450 of 1581) perceived themselves at increased risk for SD. Among survivors exposed to treatments known to be associated with SD risk, increased risk was perceived by only 33%\u201342% of males, which varied by the specific exposure. Treatment\u2010related risk factors (vs. no exposure) associated with increased perception included gonadotoxic chemotherapy (odds ratio [OR],\u00a01.6; 95% CI, 1.2\u20132.1), genitourinary\/pelvic\/spinal surgery (OR,\u00a02.6; 95% CI, 1.4\u20134.7), and pelvic\/testicular radiation (OR,\u00a01.9; 95% CI, 1.4\u20132.5). Poor mental health\u2010related quality of life (OR,\u00a02.0; 95% CI, 1.4\u20132.7) and less\u2010than\u2010excellent general health were associated with increased perception of SD risk. Men who perceived heightened SD risk reported oncologists (26.4%) and primary care providers (25.3%) as top sources of information about risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Many male survivors do not perceive heightened risks for SD, despite a history of treatment\u2010related risk factors. Because SD risk is multifactorial, oncology and survivorship providers should prioritize individualized education and counseling to improve survivors\u2019 understanding of their risk on the basis of their treatment history and current health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70599","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:43:04Z","timestamp":1789112584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Male survivors of childhood cancer and perceptions of sexual dysfunction risk: A report from the Childhood Cancer Survivor Study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-7511","authenticated-orcid":false,"given":"Jenna","family":"Demedis","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Center for Cancer and Blood Disorders Children\u2019s Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla L.","family":"Stratton","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4250-6160","authenticated-orcid":false,"given":"Tara M.","family":"Brinkman","sequence":"additional","affiliation":[{"name":"Department of Psychology and Biobehavioral Sciences St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Howell","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian R.","family":"Meacham","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta  Atlanta Georgia USA"},{"name":"Clinical Research Division and Public Health Sciences Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-961X","authenticated-orcid":false,"given":"Eric J.","family":"Chow","sequence":"additional","affiliation":[{"name":"Clinical Research Division and Public Health Sciences Division Fred Hutchinson Cancer Center  Seattle Washington 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