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Delta\u2010like ligand 3 (DLL3) has emerged as the predominant target for TCE development in SCLC given its high expression on tumor cells and relatively spared expression on normal tissues. Tarlatamab, a DLL3xCD3 TCE that is now an approved agent for SCLC, has revolutionized outcomes for patients with SCLC, but raises challenges in terms of toxicity management and real\u2010world implementation. In this review, we discuss the current landscape and future directions of DLL3\u2010targeting TCE in SCLC, including accumulating real\u2010world clinical experience, nascent investigation into patient selection and modifiers of response and resistance, and anticipated paradigm shifts as a result of ongoing clinical trials.<\/jats:p>","DOI":"10.1002\/cncr.70600","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:51:01Z","timestamp":1789113061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T\u2010cell engagers in small cell lung cancer"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-0082","authenticated-orcid":false,"given":"Alissa J","family":"Cooper","sequence":"first","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston MA 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