{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:06:30Z","timestamp":1789545990207,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salvage radiotherapy (RT) after prostatectomy is common, but studies reporting long\u2010term follow\u2010up on patient\u2010reported outcomes (PROs) and toxicity are limited. The authors report the largest cohort of patients treated with intensity modulated radiotherapy (IMRT) to date assessing patient\u2010reported quality of life (QOL) and physician\u2010rated toxicity with long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PROs were prospectively collected for men undergoing post\u2010prostatectomy salvage IMRT. Declines in quality of life were defined using established minimum clinically important difference (MCID) thresholds for bowel function (BF), sexual function (SF), urinary incontinence (UI), and urinary obstruction\/irritation (UO) domains. Physician\u2010reported genitourinary (GU) and gastrointestinal (GI) toxicities were recorded with Common Terminology Criteria for Adverse Events v3.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 2007 and 2019, 317 men were treated to a median dose of 68.4 Gy to the prostate bed with 72% receiving pelvic nodal treatment and 72% receiving androgen deprivation therapy. Median follow\u2010up was 63 months. The median scores for UI, UO, BF, and SF did not decline more than the MCID at any time point except for the 6\u2010week bowel score. At 5 years, the percentage of men with QOL decline exceeding MCID for BF, SF, UI, and UO domains were 23%, 25%, 29%, and 31%, respectively. The cumulative incidences of grade 3+ GU and GI toxicity at 5 years were 5.1% and 1.6%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Median patient\u2010reported QOL scores remained largely stable following salvage RT after radical prostatectomy, although clinically meaningful declines occurred in a subset of patients. QOL decline and physician\u2010rated toxicity were transient in approximately one\u2010third of affected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70609","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:54:00Z","timestamp":1789538040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term patient\u2010reported outcomes and toxicity following salvage radiotherapy for biochemical recurrence after radical prostatectomy"],"prefix":"10.1002","volume":"132","author":[{"given":"Connor","family":"Lynch","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzamil","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greeshma","family":"Rajeev\u2010Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-8151","authenticated-orcid":false,"given":"Ted A.","family":"Skolarus","sequence":"additional","affiliation":[{"name":"Department of Urology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-4445","authenticated-orcid":false,"given":"Parth K.","family":"Modi","sequence":"additional","affiliation":[{"name":"Department of Urology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4701-2469","authenticated-orcid":false,"given":"Stanley L.","family":"Liauw","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.04.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31553\u20101"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30454\u2010X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30456\u20103"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)31952\u20108"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.03.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01790\u20106"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/sju.v58.7318"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.06.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.05.011"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.068"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.07.024"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141639"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2018.04.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.04.085"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.08.044"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(95)00060\u2010C"},{"key":"e_1_2_8_20_1","unstructured":"National Cancer Institute Division of Cancer Treatment and Diagnosis.Common terminology criteria for adverse events (CTCAE). 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