{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:00:21Z","timestamp":1791223221543,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Improvements in therapy for patients with favorable histology Wilms tumor (FHWT) have relied on refinement of risk stratification for therapeutic assignment through identification of favorable and unfavorable prognostic factors. Although well established in International Society of Pediatric Oncology\u2010Renal Tumor Study Group protocols, the Children\u2019s Oncology Group (COG) has not historically used post\u2010chemotherapy histology (PCH) to guide therapy. This study examines whether outcomes are associated with PCH classification in the COG treatment context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors identified 2386 patients with stage III or IV FHWT enrolled on AREN0532, AREN0533, or AREN03B2\u2010only from 2006 to 2019. Inclusion criteria included delayed nephrectomy more than 5 and fewer than 16 weeks after initial biopsy, treatment on or as per protocol with DD4A or Regimen M, and known PCH classification and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 352 included patients, 45 (12.7%) were classified as low risk (LR), 287 (81.5%) as intermediate risk (IR), and 20 (5.6%) as high risk (HR). PCH classification was significantly prognostic for event\u2010free survival (EFS) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) and overall survival (OS) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001). Four\u2010year EFS for LR, IR, and HR groups was 93% (95% CI, 86%\u2013100%), 85% (95% CI, 81%\u201389%), and 53% (95% CI, 35%\u201381%); 4\u2010year OS was 96% (95% CI, 90%\u2013100%), 93% (95% CI, 89%\u201396%), and 62% (95% CI, 44%\u201389%). Compared with LR or IR, EFS and OS were significantly lower for HR, regardless of stage or treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PCH is a significant prognostic factor in unilateral FHWT treated on COG regimens, strongly supporting its incorporation into therapeutic stratification in prospective COG trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70610","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:02:25Z","timestamp":1789635745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of post\u2010chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children\u2019s Oncology Group AREN0532, AREN0533, and AREN03B2 studies"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-0007","authenticated-orcid":false,"given":"Nicholas F.","family":"Evageliou","sequence":"first","affiliation":[{"name":"Division of Oncology Department of Pediatrics Children\u2019s Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Renfro","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Southern California, and Children\u2019s Oncology Group  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Vallance","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Cook Children\u2019s Medical Center  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly R.","family":"Varela","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson, Spring House  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-3518","authenticated-orcid":false,"given":"Daniel J.","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Cost","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Urology and the Surgical Oncology Program at Children\u2019s Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-1815","authenticated-orcid":false,"given":"Peter F.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Kalapurakal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetika","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Imaging Sciences Emory University and Children\u2019s Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-1220","authenticated-orcid":false,"given":"Jennifer H.","family":"Aldrink","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Nationwide Children\u2019s Hospital The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Glick","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Cohen Children\u2019s Medical Center Zucker School of Medicine at Northwell\/Hofstra  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-542X","authenticated-orcid":false,"given":"Lauren N.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Children\u2019s Hospital of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-3045","authenticated-orcid":false,"given":"Arnold C.","family":"Paulino","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddy","family":"Artunduaga","sequence":"additional","affiliation":[{"name":"Department of Radiology Pediatric Radiology Division UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children\u2019s Hospital Medical Center University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Dix","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics BC Children\u2019s Hospital and University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad 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