{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:59:52Z","timestamp":1791223192234,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ciltacabtagene autoleucel (cilta\u2010cel), an anti\u2013B\u2010cell maturation antigen (BCMA) chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy, is approved for relapsed\/refractory multiple myeloma (RRMM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Center for International Blood and Marrow Transplant Research registry, this study evaluated outcomes of frail patients receiving commercial cilta\u2010cel from March 2022 to December 2023. Frailty was defined by an adapted simplified score incorporating age, performance status, and comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 541 patients with available frailty status, 183 (33.8%) were frail and 358 (66.2%) were nonfrail. Overall response rates were comparable (frail 82.8% vs. nonfrail 88.5%). However, frail patients had inferior progression\u2010free survival (PFS) (12\u2010month PFS, 62.7% [95% confidence interval (CI), 53.6%\u201371.3%] vs. 75.9% [95% CI, 70.4%\u201381.1%];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) and overall survival (OS) (12\u2010month OS 72.8% [95% CI, 64.9%\u201380.0%] vs. 90.4% [95% CI, 86.6%\u201393.7%];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Twelve\u2010month treatment\u2010related mortality in frail patients was 6.8% (95% CI, 3.4%\u201311.2%) versus 3.6% (95% CI, 1.8%\u20136.1%),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.12. Cytokine release syndrome (grade \u22652) occurred in 22.4% of frail versus 17.9% of nonfrail patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.05), and immune effector cell\u2013associated neurotoxicity (ICANS) of any grade was reported in 32.2% versus 17.6% (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Rates of cranial nerve palsies and Parkinsonism were comparable. Prolonged cytopenia (&gt;day 30) was more common in frail patients (30.6% vs. 21.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). On multivariable analysis, frailty independently predicted worse PFS (hazard ratio [HR], 1.67; 95% CI, 1.16\u20132.40), OS (HR, 2.46; 95% CI, 1.57\u20133.87), and higher odds of any\u2010grade ICANS (odds ratio, 2.01; 95% CI, 1.32\u20133.08) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cilta\u2010cel remains effective in frail RRMM, but frailty is associated with reduced survival and increased toxicity, supporting tailored CAR\u2010T strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70614","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:25:20Z","timestamp":1790234720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of frail patients treated with ciltacabtagene autoleucel in the real world: A Center for International Blood and Marrow Transplant Research analysis"],"prefix":"10.1002","volume":"132","author":[{"given":"Hira","family":"Mian","sequence":"first","affiliation":[{"name":"Juravinski Cancer Centre, McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Salman","family":"Faisal","sequence":"additional","affiliation":[{"name":"OU Health Stephenson Cancer Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiening","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Brazauskas","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope","family":"Oloyede","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nausheen","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimaz","family":"Afrough","sequence":"additional","affiliation":[{"name":"University of Washington\/Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center, Harold C.\u00a0Simmons Comprehensive Cancer Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-5441","authenticated-orcid":false,"given":"Rahul","family":"Banerjee","sequence":"additional","affiliation":[{"name":"University of Washington\/Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Berdeja","sequence":"additional","affiliation":[{"name":"Tennessee Oncology  Hixson Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Bidikian","sequence":"additional","affiliation":[{"name":"Yale School of Medicine\/Yale Cancer Center  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Devos","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-9742","authenticated-orcid":false,"given":"Binod","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajoy","family":"Dias","sequence":"additional","affiliation":[{"name":"National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai","family":"Dima","sequence":"additional","affiliation":[{"name":"University of Washington\/Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne A.","family":"Efebera","sequence":"additional","affiliation":[{"name":"OhioHealth  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lohith","family":"Gowda","sequence":"additional","affiliation":[{"name":"Yale School of Medicine\/Yale Cancer Center  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Landau","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazaros","family":"Lekakis","sequence":"additional","affiliation":[{"name":"University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu\u2010Sayeef","family":"Mirza","sequence":"additional","affiliation":[{"name":"H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Narra","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krina","family":"Patel","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5875-3214","authenticated-orcid":false,"given":"Ashley E.","family":"Rosko","sequence":"additional","affiliation":[{"name":"Ohio State University Comprehensive Cancer Center, James Cancer Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine\/Siteman Cancer Center  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surbhi","family":"Sidana","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Usmani","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo C.","family":"Pasquini","sequence":"additional","affiliation":[{"name":"Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2621-7924","authenticated-orcid":false,"given":"Taiga","family":"Nishihori","sequence":"additional","affiliation":[{"name":"H. 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