{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:59:52Z","timestamp":1791223192385,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early favorable prostate\u2010specific antigen (PSA) response to \u22640.2 ng\/mL by 6 months is associated with superior overall survival (OS) in metastatic hormone\u2010sensitive prostate cancer (mHSPC). The nadir androgen receptor pathway inhibitor (ARPI)\u2010derived integrative response (NADIR) model is a multivariable model developed to predict this early favorable PSA response in patients receiving ARPI. The authors report an independent external validation of the locked NADIR model in the ARCHES trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of 574 enzalutamide\u2010treated patients, 558 with complete predictors were included. Discrimination, Brier score\/index of prediction accuracy (IPA), and calibration were assessed. Predicted probability tertiles were used descriptively for PSA response. Six\u2010month landmark Cox models explored associations with OS. A sensitivity analysis restricted the cohort to &lt;3 months of prior androgen deprivation therapy (ADT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Early favorable PSA response occurred in 359 patients (64%). The area under the receiver operating characteristic curve was 0.80 (95% confidence interval [CI], 0.76\u20130.83), the Brier score was 0.17, and the IPA was 25%. Recalibration intercept was 0.026 and slope was 0.97. Response rates across decreasing predicted probability tertiles were 92%, 64%, and 37%. In the landmark analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0547; 177 deaths), each 10\u2010percentage\u2010point increase in predicted probability was associated with lower mortality (hazard ratio, 0.90; 95% CI, 0.85\u20130.96). In the &lt;3\u2010month prior\u2010ADT subgroup (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0401), the area under the receiver operating characteristic curve and IPA were 0.78 and 23%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The NADIR model demonstrates robust and reproducible discrimination, calibration, and prognostic stratification in a distinct ARPI\u2010treated mHSPC cohort, supporting its potential utility for early response risk stratification and trial enrichment pending prospective validation of model\u2010guided treatment adaptation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70615","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:56:28Z","timestamp":1790394988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["External validation of the NADIR model for early prostate\u2010specific antigen response prediction in enzalutamide\u2010treated metastatic hormone\u2010sensitive prostate cancer: An analysis of the ARCHES trial"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-5522","authenticated-orcid":false,"given":"Soumyajit","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Seidman Cancer Center Case Comprehensive Cancer Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7012-1754","authenticated-orcid":false,"given":"Andrew J.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Duke Cancer Institute Center for Prostate and Urologic Cancers  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute (NCI\u2010CCC) University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-7963","authenticated-orcid":false,"given":"Rana R.","family":"McKay","sequence":"additional","affiliation":[{"name":"UC San Diego Moores Cancer Center  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Y.","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Seidman Cancer Center Case Comprehensive Cancer Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Lichtman\u2010Mikol","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Seidman Cancer Center Case Comprehensive Cancer Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro C.","family":"Barata","sequence":"additional","affiliation":[{"name":"Division of Solid Tumor Oncology University Hospitals Seidman Cancer Center Case Comprehensive Cancer Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Division of Solid Tumor Oncology University Hospitals Seidman Cancer Center Case Comprehensive Cancer Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-7555","authenticated-orcid":false,"given":"Jason R.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Solid Tumor Oncology University Hospitals Seidman Cancer Center Case Comprehensive Cancer Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashasvi","family":"Mumgandi","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon P.","family":"Basourakos","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospitals Cleveland Medical Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris Y.","family":"Sheng","sequence":"additional","affiliation":[{"name":"Division of Solid Tumor Oncology University Hospitals Seidman Cancer Center Case Comprehensive Cancer Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar U.","family":"Kishan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology David Geffen School of Medicine University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Zaorsky","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospitals Seidman Cancer Center Case Comprehensive Cancer Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Shoag","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospitals Cleveland Medical Center Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-3346","authenticated-orcid":false,"given":"Scott C.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program The Ottawa Hospital Cancer Centre University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-4026","authenticated-orcid":false,"given":"Christopher J.\u00a0D.","family":"Wallis","sequence":"additional","affiliation":[{"name":"Division of Urology and Surgical Oncology, Department of Surgery Princess Margaret Cancer Centre University Health Network University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences 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