{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:24:38Z","timestamp":1793964278433,"version":"4.8.0"},"reference-count":53,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inotuzumab (InO)\u2010based frontline regimens have significantly improved the survival of older patients with Philadelphia\u2010negative (Ph\u2013) B\u2010cell acute lymphoblastic leukemia (B\u2010ALL). Yet, outcome after relapse is not reported for this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The retrospective RELAPSINO study describes post\u2010relapse outcome of 48 older patients treated front\u2010line with a combination of InO and low\u2010dose chemotherapy in the EWALL\u2010INO trial (NCT03249870). At relapse (91% medullary), median age was 70 years and median duration of first complete remission (CR1) 15.2 months. CD19 or CD22 expression loss was observed in respectively 13% and 23% of evaluable cases. Most patients (85%) received salvage therapy (blinatumomab, low dose or intensive chemotherapy, in combination or not). There was no InO re\u2010treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, CR2 was reached by 51% of the patients. Median event\u2010free survivals (EFS, 3.2 months) and overall survivals (OS, 4.5 months) were dismal. For patients achieving CR2, 2\u2010year OS was 46% and leukemia\u2010free survival (LFS) was 36%. By multivariable analysis, not receiving intensive chemotherapy was associated with significantly lower EFS (hazard ratio [HR], 3.28; 95% confidence interval [CI], 1.43\u20137.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.005), LFS (HR, 13.2; 95% CI, 2.46\u201370.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003), and OS (HR, 3.25; 95% CI, 1.39\u20137.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.006). CR1 duration \u226512 months was significantly associated with better EFS (HR, 0.31; 95% CI, 0.14\u20130.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003), LFS (HR, 0.16; 95% CI, 0.04\u20130.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01), and OS (HR, 0.42; 95% CI, 0.20\u20130.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.023). Not achieving CR2 was associated with lower OS (HR, 8.0; 95% CI, 3.25\u201320.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Receiving blinatumomab had no impact.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that salvage regimen should be proposed in this context, allowing 50% of patients to achieve CR2 and have better survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70621","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:28:22Z","timestamp":1790234902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcome after first relapse post\u2010immunochemotherapy in older adults with Philadelphia\u2010negative B\u2010cell acute lymphoblastic leukemia: A GRAALL study"],"prefix":"10.1002","volume":"132","author":[{"given":"Perrine","family":"Moyer","sequence":"first","affiliation":[{"name":"Clinical Hematology Department 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