{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:59:55Z","timestamp":1791223195010,"version":"4.1.0"},"reference-count":110,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Recent years have seen substantial advances in lung cancer management, with therapeutic options expanding rapidly through the integration of targeted therapies, immunotherapies, antibody\u2013drug conjugates, and novel, immune\u2010engaging agents. Although outcomes have improved for selected patients with non\u2013small cell lung cancer and small cell lung cancer, the increasing number of regimens has amplified clinical complexity, with persistent evidence gaps, limited head\u2010to\u2010head comparisons, and underrepresentation of key subgroups in trials. Emerging genomic tools and novel therapeutic modalities provide opportunities to further improve patient outcomes but also add to the challenges of clinical decision\u2010making. To address these issues, a multidisciplinary panel of oncology experts, primarily based in the United States, convened to review current evidence gaps, controversies, and unmet needs in the management of lung cancer. Key areas were identified in treatment selection and sequencing as well as the management of high\u2010risk subtypes, highlighting the need for prospective, head\u2010to\u2010head clinical trials. Findings from this panel will inform a 2026 follow\u2010up conference in which a modified Delphi method will be used to develop formal consensus recommendations to provide actionable guidance for practicing clinicians.<\/jats:p>","DOI":"10.1002\/cncr.70633","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:32:42Z","timestamp":1790652762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current challenges and emerging therapeutic strategies in lung cancer care: Insights from Bridging the Gaps 2025"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0806-6722","authenticated-orcid":false,"given":"Narjust","family":"Florez","sequence":"first","affiliation":[{"name":"Lowe Center for Thoracic Oncology Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-4840","authenticated-orcid":false,"given":"Sandip Pravin","family":"Patel","sequence":"additional","affiliation":[{"name":"Moores Cancer Center University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Salgia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Therapeutics Research City of Hope Duarte Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-7464","authenticated-orcid":false,"given":"Jacob","family":"Sands","sequence":"additional","affiliation":[{"name":"Lowe Center for Thoracic Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Schenk","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Center  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-5716","authenticated-orcid":false,"given":"Elaine","family":"Shum","sequence":"additional","affiliation":[{"name":"Department of Medicine New York University (NYU) Langone Perlmutter Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Aldea","sequence":"additional","affiliation":[{"name":"Lowe Center for Thoracic Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Gustave Roussy Sarcome  Villejuif France"},{"name":"University of Paris\u2010Saclay  Kremlin\u2010Bicetre University Library France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Bestvina","sequence":"additional","affiliation":[{"name":"The University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Donington","sequence":"additional","affiliation":[{"name":"The University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York Presbyterian  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Nieva","sequence":"additional","affiliation":[{"name":"Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1784-048X","authenticated-orcid":false,"given":"David R.","family":"Gandara","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine University of California, Davis Comprehensive Cancer Center Sacramento  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-8360","authenticated-orcid":false,"given":"Balazs","family":"Halmos","sequence":"additional","affiliation":[{"name":"Montefiore Einstein Comprehensive Cancer Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred R.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Center for Thoracic Oncology Tisch Cancer Center and Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuning","family":"Le","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Percy","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology City of Hope National Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Malhotra","sequence":"additional","affiliation":[{"name":"City of Hope  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejas","family":"Patil","sequence":"additional","affiliation":[{"name":"University of Colorado Cancer Center  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Peters","sequence":"additional","affiliation":[{"name":"Oncology Department Lausanne University Hospital\u2010Vaud  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Wesley","family":"Riess","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Internal Medicine University of California, Davis Comprehensive Cancer Center Sacramento  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Rotow","sequence":"additional","affiliation":[{"name":"Lowe Center for Thoracic Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzi Abu","family":"Rous","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Henry Ford Health  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Sabari","sequence":"additional","affiliation":[{"name":"Department of Medicine New York University (NYU) Langone Perlmutter Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triparna","family":"Sen","sequence":"additional","affiliation":[{"name":"Lung Cancer Preclinical Therapeutics Platform The Ohio State University Comprehensive Cancer Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric K.","family":"Singhi","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-5557","authenticated-orcid":false,"given":"Ana I.","family":"Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Wakelee","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Medicine Stanford University and Stanford Cancer Institute  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Therapeutics Research City of Hope Duarte Cancer Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP\u201024\u201000862"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408\u2010025\u201000801\u2010x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.75622"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137222"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.07.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2502931"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302983"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202170"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01756\u20102"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304594"},{"key":"e_1_2_7_12_1","volume-title":"Tagrisso\u00ae (osimertinib)","author":"AZ Medical Information","year":"2024"},{"key":"e_1_2_7_13_1","volume-title":"Highlights of prescribing information: Alecensa (alectinib) prescribing information","author":"Genentech USA, Inc","year":"2026"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02186"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1373388"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/00368504251383055"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304875"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2311926"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)02098\u20105"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2025.105759"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1063183"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201022\u2010390"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u20102025\u201020"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2025.15121"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010022\u201001391\u20104"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003577\u2010y"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.09.1453"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201022\u20102189"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/S43018\u2010021\u201000195\u20108"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201012\u20100108"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S335217"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3854"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01585"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.12.126"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2306441"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.08.270"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201024\u2010541"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1036334"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201025\u201000883"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.8001"},{"key":"e_1_2_7_41_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology. Non\u2013Small Cell Lung Cancer. Version 6.2026","author":"National Comprehensive Cancer Network (NCCN)","year":"2026"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027071"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698\u2010025\u201000984\u20109"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.COT.0000947668.32934.32"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2306434"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403614"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.834704"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.07.014"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2025.06.030"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002554\u20107"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.04.12"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.976731"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2026.44.16_SUPPL.8501"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31962"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.05.019"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00201"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr\u201021\u2010665"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32100554"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.01.020"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35783"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.6004\/jadpro.2024.15.8.16"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11203200"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201025\u201002023"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.43107"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201024\u20100306"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201025\u20101735"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.2147\/LCTT.S464626"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.08.002"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35784"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(25)00409\u20107"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364\u2010024\u201000566\u20100"},{"key":"e_1_2_7_72_1","volume-title":"A study of EP0031 in patients with advanced RET\u2010altered malignancies (ClinicalTrials.gov identifier NCT05443126)","author":"Ellipses Pharma","year":"2026"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.04.14"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.8015"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2021.02.014"},{"key":"e_1_2_7_76_1","unstructured":"LeeJM NegraoMV CummingsA et\u00a0al.Nautika1: clinical outcomes and pathologic regression with neoadjuvant alectinib in resectable stage IB\u2013IIIB ALK+ NSCLC [abstract OA07.05]. Paper presented at: International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC25); September 6\u20139 2025; Barcelona Spain.2025. Accessed June 7 2026.https:\/\/medically.gene.com\/global\/en\/unrestricted\/oncology\/WCLC\u20102025\/wclc\u20102025\u2010presentation\u2010lee\u2010nautika1\u2010clinical\u2010outcomes\u2010a.html"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2025.09.122"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201025\u20104382"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201020\u20101638"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.84"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1366260"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.70052"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00174"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32409\u20107"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801005"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2025.115748"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11409"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.70033"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010019\u20100028\u20101"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02722\u20103"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_SUPPL.TPS8652"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO\u201024\u201001544"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010024\u201000914\u2010x"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809064"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32222\u20106"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010023\u201005544\u2010x"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02212"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.09.009"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01363"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15164016"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010019\u20100133\u20109"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026821\u20108"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307980"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(20)30068\u20101"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010024\u201002012\u2010z"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2023.101801"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.08.763"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02823"},{"key":"e_1_2_7_109_1","volume-title":"Small Cell Lung Cancer, Version 1.2027","author":"National Comprehensive Cancer Network (NCCN)","year":"2026"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2502099"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.0698"}],"container-title":["Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cncr.70633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncr.70633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:46:51Z","timestamp":1791222411000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncr.70633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":110,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1002\/cncr.70633"],"URL":"https:\/\/doi.org\/10.1002\/cncr.70633","archive":["Portico"],"relation":{},"ISSN":["0008-543X","1097-0142"],"issn-type":[{"value":"0008-543X","type":"print"},{"value":"1097-0142","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2026-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70633"}}