{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:42:54Z","timestamp":1792665774297,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1U10 CA180822"],"award-info":[{"award-number":["1U10 CA180822"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180868"],"award-info":[{"award-number":["U10CA180868"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The NRG\u2010GY012 phase 2 trial evaluated olaparib, cediranib, and the combination in 120 patients with recurrent, persistent, or metastatic endometrial cancer (EC). Predictive and prognostic associations between blood\u2010based biomarkers and clinical outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Plasma samples collected at baseline, cycle 4 day 1, and disease progression were analyzed for circulating protein biomarkers (Angiome). The primary analysis evaluated the predictive impact of IL\u20106 on progression\u2010free survival (PFS) and overall survival (OS). The predictive and prognostic impact of all other markers on PFS and OS were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010six baseline plasma samples were included in this analysis. Results from GOG\u2010218 identified IL\u20106 was predictive of clinical benefit using a threshold of 2.9 pg\/mL. Although the 2.9 pg\/mL cut point did not validate in GY012, IL\u20106 associated with OS using the median level of 4.2 pg\/mL as the cut point. Although patients with &gt;4.2 pg\/mL IL\u20106 had worse prognosis, higher IL\u20106 levels were associated with longer OS benefit in the cediranib arms (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>intx<\/jats:sub>\n                      \u00a0=\u00a0.085). In secondary analyses, osteopontin (OPN) and placental growth factor (PlGF) potentially predicted benefit. Patients with higher OPN levels had shorter OS in the olaparib arm, whereas patients with lower OPN had longer OS in the cediranib arms (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>intx<\/jats:sub>\n                      \u00a0=\u00a0.035). Patients with higher PlGF benefited more from cediranib (PFS,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>intx<\/jats:sub>\n                      \u00a0=\u00a0.030; OS,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>intx<\/jats:sub>\n                      \u00a0=\u00a0.024). Multiple prognostic markers were also identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL\u20106 may be predictive of outcome; OPN and PlGF represent novel potential predictive biomarkers, in EC patients receiving anti\u2010angiogenic therapy. Further evaluation is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncr.70649","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:32:26Z","timestamp":1791963146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood\u2010based biomarkers in patients with recurrent, persistent, or metastatic endometrial cancer treated with olaparib and cediranib: Results from NRG\u2010GY012"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-2964","authenticated-orcid":false,"given":"Andrew B.","family":"Nixon","sequence":"first","affiliation":[{"name":"Department of Medicine Duke Cancer Institute Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Enserro","sequence":"additional","affiliation":[{"name":"NRG Oncology, Clinical Trials Development Division, Biostatistics &amp; Bioinformatics Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Bender","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingmiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke Cancer Institute Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Starr","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke Cancer Institute Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan S.","family":"Veljovich","sequence":"additional","affiliation":[{"name":"St. Luke\u2019s Cancer Institute  Boise Idaho USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Fehniger","sequence":"additional","affiliation":[{"name":"Legacy Good Samaritan Hospital and Medical Center  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Moroney","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-6913","authenticated-orcid":false,"given":"Floor J.","family":"Backes","sequence":"additional","affiliation":[{"name":"The Ohio State University Comprehensive Cancer Center  Hilliard Ohio 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