{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:27:23Z","timestamp":1760315243732,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T00:00:00Z","timestamp":1234828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2009,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The diagnosis of low\u2010grade squamous intraepithelial lesion (LSIL), cannot exclude high\u2010grade squamous intraepithelial lesion (LSIL\u2010H) was not included in the 2001 Bethesda System. It is used in some institutions to diagnose cases that fulfill criteria for both the diagnosis of LSIL and atypical squamous cells, cannot exclude high\u2010grade squamous intraepithelial lesion (ASC\u2010H). In this study, the authors reviewed their experience with cases reported as LSIL\u2010H during a 4\u2010year interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Clinical information and histologic follow\u2010up data were retrieved for Papanicolaou (Pap) tests (PTs) that were diagnosed as LSIL\u2010H, LSIL, ASC\u2010H and high\u2010grade squamous intraepithelial lesion (HSIL) from January 1, 2004 to December 31, 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Of 235,645 PTs (97% SurePath) that were processed during the study period, the laboratory diagnosed 0.52% as ASC\u2010H, 2% as LSIL, 0.30% as LSIL\u2010H, and 0.39% as HSIL. Biopsy follow\u2010up was available for 47%, 49%, 56.7% and 74% of these cases, respectively. Cervical intraepithelial neoplasia 2 (CIN\u20102) and CIN\u20103 or more severe lesions (CIN\u20103+) were identified on follow\u2010up cervical biopsy more often in women who had diagnoses of LSIL\u2010H and ASC\u2010H (33.14% and 26.33%, respectively) than in women who had a diagnosis of LSIL (16.11%).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The similarity of histologic follow\u2010up results between LSIL\u2010H and ASC\u2010H suggested that the management of women who have a diagnosis of LSIL\u2010H should be similar to the management of women who have a diagnosis of ASC\u2010H. Cancer (Cancer Cytopathol) 2009. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.20004","type":"journal-article","created":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T12:36:59Z","timestamp":1234874219000},"page":"92-100","source":"Crossref","is-referenced-by-count":18,"title":["Clinical significance of the diagnosis of low\u2010grade squamous intraepithelial lesion, cannot exclude high\u2010grade squamous intraepithelial lesion"],"prefix":"10.1002","volume":"117","author":[{"given":"Mariam","family":"Alsharif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klint","family":"Kjeldahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Curran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelby","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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