{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T22:10:26Z","timestamp":1760307026945,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T00:00:00Z","timestamp":1251244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2009,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Screening for cervical cancer precursors has evolved considerably with the introduction of new technologies to improve the early detection of disease. The objective of this study was to analyze the accuracy and effectiveness of combined screening with cytology and high\u2010risk human papillomavirus (HR\u2010HPV) testing in a low\u2010risk population of women aged \u226530 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Consecutive unselected samples from a group of 1871 women aged \u226530 years were screened with image\u2010guided ThinPrep tests and HR\u2010HPV tests during a 6\u2010month period. Histologic follow\u2010up was reviewed among women with positive HR\u2010HPV tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A total of 85 (4.5%) women had positive HR\u2010HPV tests. In 48 HR\u2010HPV\u2013positive women with follow\u2010up biopsies, 41 (85%) were found to have histologic abnormalities. Thirty\u2010three (1.9%) women with cytologically normal Papanicolaou (Pap) tests harbored HR\u2010HPV, and a cervical intraepithelial neoplasia (CIN) 2+ lesion was detected in 1 (16%) of 6 women with histologic follow\u2010up. Conversely, 2 (28%) of 7 women with high\u2010grade intraepithelial lesion on cytology tested negative for HR\u2010HPV during the same period. A case of serous carcinoma with atypical glandular cells on cytology was also negative for HR\u2010HPV, as expected.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>In this low\u2010risk population of women aged \u226530 years, histology\u2010confirmed CIN2+ lesions were identified in women with negative cytology and positive HR\u2010HPV tests, as well as in those with positive cytology and negative HR\u2010HPV tests. Because both cytology and HPV testing alone missed significant lesions, cotesting with Pap and HR\u2010HPV in women aged \u226530 years appears to be a reasonable option in a low\u2010risk population. (Cancer Cytopathol) 2009. \u00a9 2009 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.20038","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T23:51:33Z","timestamp":1251330693000},"page":"326-332","source":"Crossref","is-referenced-by-count":7,"title":["Image\u2010guided ThinPrep Papanicolaou tests and cotesting with high\u2010risk human papillomavirus in women aged 30 years and older in a low\u2010risk private practice population"],"prefix":"10.1002","volume":"117","author":[{"given":"Yimin","family":"Ge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary R.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina R.","family":"Mody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_2","DOI":"10.1002\/ijc.22527"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_2","DOI":"10.1067\/mob.2001.116736"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5858\/2004-128-17-COPOCA","article-title":"Comparison of performance of conventional and ThinPrep gynecologic preparations in the College of American Pathologists Gynecologic Cytology Program","volume":"128","author":"Renshaw AA","year":"2004","journal-title":"Arch Pathol Lab Med."},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_2","DOI":"10.1002\/cncr.11786"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_2","DOI":"10.1016\/S0090-8258(03)00176-8"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_2","DOI":"10.1016\/j.ygyno.2006.07.025"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_2","DOI":"10.1159\/000325959"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_2","DOI":"10.1186\/1742-6413-4-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_2","DOI":"10.1097\/00128360-200304000-00001"},{"key":"e_1_2_6_11_2","first-page":"237","article-title":"ACOG practice bulletin. 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