{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:49:37Z","timestamp":1778935777334,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T00:00:00Z","timestamp":1299801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2011,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Although a wide variety of papillary carcinomas of the thyroid can have abundant granular cytoplasm and may be difficult to distinguish from H\u00fcrthle cell lesions in fine\u2010needle aspirations (FNAs), the literature on these tumors is limited. The author described 18 cases with a spectrum of cytologic appearances.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A series of 7089 FNAs was correlated with 1331 subsequent resection specimens. Cases in which the original cytologic and histologic diagnoses included the differential diagnosis of papillary carcinoma or H\u00fcrthle cell lesions were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A total of 18 (1.3% of cases with resection) cases were identified. On review, 3 cases had classic features of papillary carcinoma, including nuclear crowding, along with a moderate amount of granular cytoplasm. Four cases had a population of cells that mimicked repair and\/or cyst\u2010lining cells with almost no other epithelial cells. In 2 of those 4 cases, the cells were extremely large, and in 2 other cases, they could not be distinguished from typical cyst\u2010lining cells. The remaining 11 cases had cells with overlapping features including pale to granular chromatin, small to medium nucleoli either centrally or eccentrically, occasional grooves, and rare intranuclear inclusions. Typical H\u00fcrthle cells also were commonly present. Nuclear crowding was not present, and the cells were in sheets, follicles, or appeared alone. No papillae were identified. On resection, 7 cases were follicular variants of papillary carcinoma, 2 cases occurred in the setting of Hashimoto thyroiditis, and 2 cases had features of the tall\u2010cell variant.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The author concluded that a subset of papillary carcinomas of the thyroid were difficult to distinguish from H\u00fcrthle cell lesions or repair and\/or cyst\u2010lining cells because of the presence of abundant granular cytoplasm and a lack of nuclear crowding. These tumors were often follicular or cystic variants of papillary carcinoma. Cancer (Cancer Cytopathol) 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.20148","type":"journal-article","created":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T09:32:34Z","timestamp":1299835954000},"page":"247-253","source":"Crossref","is-referenced-by-count":9,"title":["Fine\u2010needle aspirations of papillary carcinoma with oncocytic features"],"prefix":"10.1002","volume":"119","author":[{"given":"Andrew A.","family":"Renshaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20132"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-87666-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90278-1"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP0RW2WMDUAKGK"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840070114"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890215)63:4<718::AID-CNCR2820630420>3.0.CO;2-N"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000334035"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326306"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21281"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.5858\/2000-124-1192-WLPCOT","article-title":"Warthin\u2010like papillary carcinoma of the thyroid","volume":"124","author":"Baloch ZW","year":"2000","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1309\/CJEU-XLQ7-UPVE-NWFV"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPKP2QUVN4RCCP"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20041"},{"key":"e_1_2_6_15_2","volume-title":"Color Atlas of Differential Diagnoses in Exfoliative and Aspiration Cytopathology","author":"Kini SR","year":"1999"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10715"},{"key":"e_1_2_6_17_2","first-page":"64A","article-title":"Atypical thyroid cyst lining cells: a pitfall for the FNA diagnosis of cystic thyroid lesions [abstract]","volume":"16","author":"Faquin WC","year":"2003","journal-title":"Mod Pathol."}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.20148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.20148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:00:36Z","timestamp":1760274036000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.20148"}},"subtitle":["An expanded cytologic and histologic profile"],"short-title":[],"issued":{"date-parts":[[2011,3,11]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8,25]]}},"alternative-id":["10.1002\/cncy.20148"],"URL":"https:\/\/doi.org\/10.1002\/cncy.20148","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,11]]}}}