{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:42Z","timestamp":1786977402212,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T00:00:00Z","timestamp":1304985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2011,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      B\u2010cell lymphomas with concurrent\n                      <jats:italic>IGH\u2010BCL2<\/jats:italic>\n                      and\n                      <jats:italic>c\u2010MYC<\/jats:italic>\n                      rearrangements (so\u2010called \u201cdouble\u2010hit lymphomas\u201d [DHL]) are a relatively rare, recently described category in the 2008 World Health Organization classification of hematopoietic neoplasms. Response to chemotherapy and survival are poor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The authors reviewed files of cytogenetically documented DHL to identify cytologic features that would allow its possible recognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Twelve fine\u2010needle aspirates (FNAs), 2 pleural fluids, and 1 touch imprint of cytogenetically proven DHL were uncovered. Primary DHL was correctly recognized in 3 of 12 FNA cases using Ki\u201067 staining coupled with a positive bcl\u20102 result as the basis for performing fluorescence in situ hybridization (FISH) analysis of\n                      <jats:italic>c\u2010MYC<\/jats:italic>\n                      and\n                      <jats:italic>IGH\u2010BCL2<\/jats:italic>\n                      rearrangements. Remaining FNAs and non\u2010FNA cases were diagnosed as non\u2010Hodgkin lymphoma, B\u2010cell lymphoma, or atypical lymphocytosis. Ten cases had cell block material available. All cases had high cellularity with a dissociated smear pattern and background lymphoglandular bodies. Cell size ranged from intermediate to large. Nuclei were predominantly rounded or slightly irregular in contour; 4 FNAs had markedly cleaved nuclei. Some nuclei harbored discrete but small nucleoli, whereas in others coarse chromatin and indistinct or multiple small nucleoli existed. A variable number of mitotic figures, tingible body macrophages, and background apoptotic cells were also present.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      No specific cytomorphologic feature(s) were found to reliably identify DHL using FNA or exfoliative cytology. A high Ki\u201067 proliferation index and positive bcl\u20102 staining (on cytospin slides or cell block material) of cases not conforming to typical Burkitt lymphoma morphology should prompt FISH analysis for\n                      <jats:italic>c\u2010MYC<\/jats:italic>\n                      and\/or\n                      <jats:italic>IGH\u2010BCL2<\/jats:italic>\n                      rearrangements to identify DHL, particularly if tissue biopsy is not expected. Cancer (Cancer Cytopathol) 2011;. \u00a9 2011 American Cancer Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cncy.20160","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T11:21:24Z","timestamp":1305026484000},"page":"263-271","source":"Crossref","is-referenced-by-count":26,"title":["Cytopathology of \u201cdouble\u2010hit\u201d non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"119","author":[{"given":"Camille T.","family":"Elkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Paul E.","family":"Wakely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/103.4.472"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711053171904"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.281"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055351"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3152"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-297879"},{"key":"e_1_2_6_8_2","volume-title":"WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues","author":"Swerdlow HS","year":"2008"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cd3aeb"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000180442.87022.08"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.104"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20075"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20098"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20040"},{"key":"e_1_2_6_15_2","first-page":"344","volume-title":"Cytology: Diagnostic Principles and Clinical Correlates","author":"Wakely PE","year":"2009"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.20160","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.20160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:00:37Z","timestamp":1760274037000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.20160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,10]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8,25]]}},"alternative-id":["10.1002\/cncy.20160"],"URL":"https:\/\/doi.org\/10.1002\/cncy.20160","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,10]]}}}