{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:41:49Z","timestamp":1760276509384,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T00:00:00Z","timestamp":1309824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2011,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The role of testing for high\u2010risk human papillomavirus (HR HPV) when triaging women with a cytologic diagnosis of low\u2010grade squamous intraepithelial lesion (LSIL) has not been well established. The objective of the current study was to correlate the status of HR HPV with the incidence of cervical intraepithelial neoplasia 2 and more severe lesions (CIN 2+) on tissue follow\u2010up in women with LSIL.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 1046 women with LSIL and HR HPV testing were identified in the database of a large teaching hospital within a 12\u2010month period. HR HPV testing was performed using the Hybrid Capture 2 assay with 1 relative light unit\/cutoff as the cutoff.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of the 1046 women with LSIL and concurrent HR HPV testing, 82.3% tested positive for HR HPV, 91.1% of whom were women aged &lt; 30 years and 73% of whom were women aged \u2265 30 years (<jats:italic>P<\/jats:italic> &lt; .001). Cytologic and\/or histologic follow\u2010up was available in 979 (93.6%) women; 25.5% had negative follow\u2010up, 62.5% were found to have CIN 1 lesions, and 12.0% had CIN 2+ lesions. The sensitivity and negative predictive value of HR HPV status as a marker of CIN 2+ lesions were 98.3% and 98.9%, respectively. The colposcopy rate was 73.3% and 96.9% for women aged \u2265 30 years and women aged &lt; 30 years, respectively (<jats:italic>P<\/jats:italic> = .01).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Using 1 RLU\/CO as the cutoff value, HR HPV testing was found to be highly sensitive for detecting CIN 2+ lesions in women with LSIL. The colposcopy rate was significantly lower in women aged \u2265 30 years compared with women aged &lt; 30 years. Triaging with HR HPV testing may be indicated in women aged \u2265 30 years with LSIL cytology, but not in women aged &lt; 30 years. Cancer (Cancer Cytopathol) 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.20172","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T12:27:22Z","timestamp":1309868842000},"page":"228-234","source":"Crossref","is-referenced-by-count":10,"title":["Use of high\u2010risk human papillomavirus testing in patients with low\u2010grade squamous intraepithelial lesions"],"prefix":"10.1002","volume":"119","author":[{"given":"Angelique W.","family":"Levi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malini","family":"Harigopal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Chhieng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.5.397"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.11.013"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21209"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38701.440961.7C"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00631.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.2.102"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e3e719"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj209"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00245-2"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.01.043"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601185343"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.5858\/2009-0624-OA.1","article-title":"Significance of high\u2010risk human papillomavirus DNA detection in women 50 years and older with squamous cell papanicolaou test abnormalities","volume":"134","author":"Zhao C","year":"2010","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6336"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00529-X"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.5858\/2008-132-1290-HPTARR","article-title":"Human papillomavirus testing and reporting rates: practices of participants in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytology in 2006","volume":"132","author":"Moriarty AT","year":"2008","journal-title":"Arch Pathol Lab Med."}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.20172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.20172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:00:40Z","timestamp":1760274040000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.20172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,5]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8,25]]}},"alternative-id":["10.1002\/cncy.20172"],"URL":"https:\/\/doi.org\/10.1002\/cncy.20172","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"type":"print","value":"1934-662X"},{"type":"electronic","value":"1934-6638"}],"subject":[],"published":{"date-parts":[[2011,7,5]]}}}