{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:42:34Z","timestamp":1777948954473,"version":"3.51.4"},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T00:00:00Z","timestamp":1311033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2011,12,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The study documents histopathologic outcomes and high\u2010risk (hr) human papillomavirus (HPV) test results in a large cohort of patients with high\u2010grade squamous intraepithelial lesion (HSIL) liquid\u2010based cytology (LBC) Pap test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A total of 352 patients with HSIL results (338 cervical and 14 vaginal) who had hrHPV testing and 290 patients with biopsy follow\u2010up were studied. hrHPV detection rates were compared at different ages, with or without an endocervical\/transformation zone sample (EC\/TZS), and for cervical and vaginal HSIL Pap smears. Histopathologic follow\u2010up findings were also compared. hrHPV\u2010negative HSIL slides were re\u2010evaluated in a blinded manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>A total of 325 of 338 (96.2%) cervical HSIL and 12 of 14 (87.5%) vaginal HSIL tested hrHPV\u2010positive. A total of 271 of 281 (96.4%) EC\/TZS\u2010positive cervical HSIL and 54 of 57 (94.7%) EC\/TZS\u2010negative cervical HSIL tested hrHPV\u2010positive. The percentage of hrHPV\u2010positive HSIL declined slightly with increasing age. 197 of 273 (72.3%) hrHPV\u2010positive cervical HSIL had histopathologic cervical intraepithelial neoplasia (CIN) 2\/3+ follow\u2010up, including 8 squamous carcinomas, compared with 4 of 12 (33.3%) hrHPV\u2010negative HSIL with CIN2\/3 (no carcinomas). 167 of 241 (69.2%) EC\/TZS\u2010positive HSIL had CIN2\/3+ follow\u2010up, compared with 34 of 44 (77.3%) EC\/TZS\u2010negative HSIL. Equivocal HSIL morphology characterized some HPV\u2010negative HSIL without CIN2\/3+ follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>hrHPV was detected in LBC vials from 96.2% of 338 cervical HSIL and 85.7% of 14 vaginal HSIL. CIN2\/3+ was significantly more likely with hrHPV\u2010positive cervical HSIL than with hrHPV\u2010negative cervical HSIL. Presence or absence of an EC\/TZS did not significantly impact HSIL hrHPV or CIN2\/3+ rates. Some hrHPV\u2010negative HSIL cases may represent HSIL cytologic mimics. Cancer (Cancer Cytopathol) 2011;. \u00a9 2011 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.20176","type":"journal-article","created":{"date-parts":[[2011,7,19]],"date-time":"2011-07-19T12:50:16Z","timestamp":1311079816000},"page":"377-386","source":"Crossref","is-referenced-by-count":24,"title":["Histopathologic follow\u2010up and human papillomavirus DNA test results in 290 patients with high\u2013grade squamous intraepithelial lesion papanicolaou test results"],"prefix":"10.1002","volume":"119","author":[{"given":"Faye F.","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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