{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:46:32Z","timestamp":1790185592369,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2012,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Intrapancreatic accessory spleen (IPAS) is a rare benign lesion of the pancreas that frequently clinically and radiographically mimics a solid neoplasm. Very rarely, epidermoid cysts may form in IPAS and be mistaken for a cystic neoplasm of the pancreas on radiographic imaging. IPAS and epidermoid cyst involving intrapancreatic cyst (ECIPAS) are benign, and, if recognized, do not require surgical intervention. There are few reports of the cytopathologic features of IPAS diagnosed by fine\u2010needle aspiration (FNA).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>Here we report a series of 6 cases of endoscopic ultrasound (EUS)\u2010guided FNA of IPAS, 3 of which had histological confirmation, including 1 case of histologically confirmed ECIPAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Cytomorphologic features of IPAS include a polymorphous population of hematopoietic cells, including lymphocytes, eosinophils, histiocytes, plasma cells, and red blood cells, admixed with numerous small blood vessels representing splenic sinusoids. CD8 immunostaining of cell block or core biopsy material highlights splenic endothelial cells and confirms the diagnosis. FNA of ECIPAS reveals predominantly macrophages and proteinaceous debris.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Diagnostic pitfalls include pancreatic neuroendocrine tumor. If IPAS is recognized as a diagnostic consideration on EUS\u2010FNA, unnecessary surgical resection may be avoided. Cancer (Cancer Cytopathol) 2012. \u00a9 2012 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21185","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T12:18:21Z","timestamp":1328098701000},"page":"261-268","source":"Crossref","is-referenced-by-count":42,"title":["Fine\u2010needle aspiration of intrapancreatic accessory spleen: Cytomorphologic features and differential diagnosis"],"prefix":"10.1002","volume":"120","author":[{"given":"Armanda D.","family":"Tatsas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momin T.","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph H.","family":"Hruban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Z.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"652","article-title":"Accessory spleens in or at the tail of the pancreas. A survey of 2,700 additional necropsies","volume":"77","author":"Halpert B","year":"1964","journal-title":"Arch Pathol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.5858\/2010-0238-CR.1","article-title":"Fine\u2010needle aspiration of intrapancreatic accessory spleen, mimic of pancreatic neoplasms","volume":"134","author":"Lin J","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325047"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20801"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308048"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-009-9229-y"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-007-1243-4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181359e36"},{"key":"e_1_2_5_10_2","first-page":"279","article-title":"Epidermoid cyst occurring within an intrapancreatic accessory spleen. 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