{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:18:10Z","timestamp":1790050690784,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2012,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Nodular lymphocyte\u2010predominant Hodgkin lymphoma (NLPHL), a rare subtype of Hodgkin lymphoma, is an indolent tumor with frequent instances of disease recurrence but a favorable prognosis. To the best of the authors' knowledge, there are only limited descriptions of NLPHL in the cytology literature because it was only formally recognized as a distinct entity in 1994.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>In the current study, all cases of NLPHL diagnosed on excisional biopsy (n = 6 cases) at the study institution between 2000 and 2011 that had undergone previous fine\u2010needle aspiration (FNA) were reviewed, with a focus on cytomorphologic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>Four of 6 cases were termed benign on FNA; however, there was retrospective recognition of characteristic LP cells in all cases. Unlike classical Hodgkin lymphoma, the tumor cells of NLPHL were often found to be mononucleate and presented in a background of small lymphocytes. Other features identified included epithelioid histiocytes and numerous bare atypical nuclei.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Cases of NLPHL are commonly misdiagnosed as benign reactive lymphoid tissue and therefore a careful search using high magnification for LP cells is recommended in the evaluation of lymph node FNAs. Cancer (Cancer Cytopathol) 2012;. \u00a9 2012 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21186","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T11:13:45Z","timestamp":1330082025000},"page":"254-260","source":"Crossref","is-referenced-by-count":23,"title":["Nodular lymphocyte\u2010predominant Hodgkin lymphoma"],"prefix":"10.1002","volume":"120","author":[{"given":"Andrea P.","family":"Subhawong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Z.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armanda D.","family":"Tatsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1182\/blood.V85.3.857.bloodjournal853857","article-title":"Lymphoma classification proposal: clarification","volume":"85","author":"Harris NL","year":"1995","journal-title":"Blood."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.584993"},{"key":"e_1_2_6_4_2","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.11.821"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326036"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20439"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21472"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21455"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20487"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11903"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10195"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326228"},{"key":"e_1_2_6_15_2","article-title":"T\u2010cell\u2013rich B\u2010cell lymphoma (TCRBCL): limitations in fine\u2010needle aspiration cytodiagnosis [published online ahead of print April 6, 2011]","author":"Das DK","journal-title":"Diagn Cytopathol."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200310000-00007"}],"container-title":["Cancer Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcncy.21186","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cncy.21186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:02:47Z","timestamp":1760299367000},"score":1,"resource":{"primary":{"URL":"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/10.1002\/cncy.21186"}},"subtitle":["Cytopathologic correlates on fine\u2010needle aspiration"],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8,25]]}},"alternative-id":["10.1002\/cncy.21186"],"URL":"https:\/\/doi.org\/10.1002\/cncy.21186","archive":["Portico"],"relation":{},"ISSN":["1934-662X","1934-6638"],"issn-type":[{"value":"1934-662X","type":"print"},{"value":"1934-6638","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]}}}