{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:07:35Z","timestamp":1769598455595,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T00:00:00Z","timestamp":1339632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2012,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The best method for identifying women who have minor cervical lesions that require diagnostic workup remains unclear. The authors of this report performed a meta\u2010analysis to assess the accuracy of cyclin\u2010dependent kinase inhibitor 2A (p16<jats:sup>INK4a<\/jats:sup>) immunocytochemistry compared with high\u2010risk human papillomavirus DNA testing with Hybrid Capture 2 (HC2) to detect grade 2 or greater cervical intraepithelial neoplasia (CIN2+) and CIN3+ among women who had cervical cytology indicating atypical squamous cells of undetermined significance (ASC\u2010US) or low\u2010grade cervical lesions (LSIL). A literature search was performed in 3 electronic databases to identify studies that were eligible for this meta\u2010analysis. Seventeen studies were included in the meta\u2010analysis. The pooled sensitivity of p16<jats:sup>INK4a<\/jats:sup> to detect CIN2+ was 83.2% (95% confidence interval [CI], 76.8%\u201088.2%) and 83.8% (95% CI, 73.5%\u201090.6%) in ASC\u2010US and LSIL cervical cytology, respectively, and the pooled specificities were 71% (95% CI, 65%\u201076.4%) and 65.7% (95% CI, 54.2%\u201075.6%), respectively. Eight studies provided both HC2 and p16<jats:sup>INK4a<\/jats:sup> triage data. p16<jats:sup>INK4a<\/jats:sup> and HC2 had similar sensitivity, and p16<jats:sup>INK4a<\/jats:sup> has significantly higher specificity in the triage of women with ASC\u2010US (relative sensitivity, 0.95 [95% CI, 0.89\u20101.01]; relative specificity, 1.82 [95% CI, 1.57\u20102.12]). In the triage of LSIL, p16<jats:sup>INK4a<\/jats:sup> had significantly lower sensitivity but higher specificity compared with HC2 (relative sensitivity, 0.87 [95% CI, 0.81\u20100.94]; relative specificity, 2.74 [95% CI, 1.99\u20103.76]). The published literature indicated the improved accuracy of p16<jats:sup>INK4a<\/jats:sup> compared with HC2 testing in the triage of women with ASC\u2010US. In LSIL triage, p16<jats:sup>INK4a<\/jats:sup> was more specific but less sensitive. Cancer (Cancer Cytopathol) 2012. \u00a9 2012 American Cancer Society.<\/jats:p>","DOI":"10.1002\/cncy.21205","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T10:42:52Z","timestamp":1339670572000},"page":"294-307","source":"Crossref","is-referenced-by-count":69,"title":["p16<sup>INK4a<\/sup> immunocytochemistry versus human papillomavirus testing for triage of women with minor cytologic abnormalities"],"prefix":"10.1002","volume":"120","author":[{"given":"Jolien","family":"Roelens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Reuschenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"von Knebel Doeberitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Wentzensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Arbyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr015"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.07.016"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jnci\/93.4.293","article-title":"Comparison of 3 management strategies for patients with atypical squamous cells of undetermined significance (ASCUS): baseline results from a randomized trial","volume":"93","author":"Solomon D","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh037"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21232"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00631.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1309\/BEPQXTCQD61RGFMJ"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009933108"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1174"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/678793"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20140"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.10.005"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24774"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jama.1989.03430070079034","article-title":"The 1988 Bethesda System for reporting cervical\/vaginal cytologic diagnoses","volume":"262","author":"Lundberg GD","year":"1989","journal-title":"JAMA"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.9.933"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2002.00448_1.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-25"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxl004"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0900900203"},{"key":"e_1_2_6_22_2","volume-title":"METADAS: A SAS Macro for Meta\u2010Analysis of Diagnostic Accuracy Studies","author":"Takwoingi Y","year":"2009"},{"key":"e_1_2_6_23_2","unstructured":"Diagnostic Test Accuracy Working Group. 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