{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:14:50Z","timestamp":1761988490783,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T00:00:00Z","timestamp":1338336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2012,12,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>The 2001 Bethesda System for gynecologic cervical cytology reporting classifies squamous intraepithelial lesions into low\u2010grade (LSIL) and high\u2010grade (HSIL) lesions. An intermediate term, \u201clow\u2010grade squamous intraepithelial lesion, cannot exclude high\u2010grade squamous intraepithelial lesion (LSIL\u2010H),\u201d has been used in a small percentage of LSIL cases. To the authors' knowledge, little is known regarding the human papillomavirus (HPV) status in patients with LSIL\u2010H.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p>A total of 808 SurePath specimens obtained between December 2009 and April 2011 were tested for 40 HPV genotypes using DNA microarray, followed by a confirmatory DNA sequencing assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The infection rate for high\u2010risk HPV in women with LSIL\u2010H (92%) was strikingly close to that for women with HSIL (91%), which was higher than that for those with LSIL (74%); atypical squamous cells, cannot rule out high\u2010grade lesion (ASC\u2010H) (78%); or LSIL and ASC\u2010H combined (74%). HPV type 16, the most common carcinogenic HPV genotype, was detected in 36% of women with LSIL\u2010H, which was significantly higher than that in women with LSIL and ASC\u2010H combined (13.8%), but less than that in women with HSIL (44.6%). Patients with LSIL\u2010H and HSIL had similar infection rates for low\u2010risk\/intermediate\u2010risk HPV genotypes, which were lower than those in LSIL or LSIL and ASC\u2010H combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>Women found to have LSIL\u2010H on a Papanicolaou test appear to have a unique HPV distribution pattern that clearly differs from LSIL and is comparable to that for HSIL, suggesting an increased risk of high\u2010grade lesions over that of women with LSIL. Recognizing LSIL\u2010H as an independent diagnostic category may help in the early identification of the high\u2010risk subgroup that may require a management algorithm comparable to that for patients with HSIL. Cancer (Cancer Cytopathol) 2012. \u00a9 2012 American Cancer Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21210","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T16:51:06Z","timestamp":1338396666000},"page":"373-379","source":"Crossref","is-referenced-by-count":9,"title":["Should LSIL\u2010H be a distinct cytology category?"],"prefix":"10.1002","volume":"120","author":[{"given":"Haijun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary R.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Coffey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina R.","family":"Mody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_7_4_2","first-page":"857","article-title":"Clinical significance of the Pap smear diagnosis of LSIL cannot exclude HSIL: comparison with a patient population with Pap smear findings of LSIL [abstract]","volume":"44","author":"Walsh BG","year":"2000","journal-title":"Acta Cytol."},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200010)23:4<245::AID-DC6>3.0.CO;2-7"},{"key":"e_1_2_7_6_2","first-page":"462","article-title":"Reporting of \u201cLSIL with ASC\u2010H\u201d 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