{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:17:04Z","timestamp":1761988624981,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Atypical glandular cells (AGC) is a very important diagnosis in gynecological cytology. In the current study, the authors investigated the usefulness of Cellient cell blocks (CB) for characterizing AGC on Papanicolaou (Pap) tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A total of 148 patients with an AGC diagnosis based on Pap tests by cytotechnologists and referred to cytopathologists were studied. Among these patients, there were 68 patients with CB preparations and 80 patients with Pap tests only (TP\u2010AGC group). Follow\u2010up results by Pap tests or biopsies were obtained in 117 of 148 patients. The median follow\u2010up was 13 months (range, 1 month\u201036 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of the 68 patients with CBs, 31 (46%) were reclassified as negative for dysplasia or low\u2010grade intraepithelial lesion; 30 patients (44%) retained a diagnosis of AGC (CB\u2010AGC group); and 7 patients (10%) were given specific diagnoses of high\u2010grade intraepithelial lesion (3 patients), endocervical adenocarcinoma in situ (1 patient), and invasive adenocarcinoma (3 patients). On follow\u2010up, the CB\u2010AGC group was found to have a significantly lower rate of negative\/low\u2010grade squamous intraepithelial lesion diagnoses compared with the TP\u2010AGC group (55% vs 85%; <jats:italic>P<\/jats:italic>\u2009=\u2009.006). The CB\u2010AGC group had a significantly higher rate of endocervical or endometrial adenocarcinoma compared with the TP\u2010AGC group (36% vs 8%; <jats:italic>P<\/jats:italic>\u2009=\u2009.003) at the time of follow\u2010up. The rates of high\u2010grade squamous intraepithelial lesion were not found to be statistically different between these 2 groups (9% vs 7%; <jats:italic>P<\/jats:italic>\u2009=\u2009.66).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The Cellient CB is a useful technique to further categorize a diagnosis of AGC on Pap tests. Using the Cellient CB system, the pathologist has the ability to improve the diagnostic accuracy of AGC so that unnecessary colposcopic evaluation or biopsies can be avoided. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2014;122:8\u201314<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21343","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T16:28:51Z","timestamp":1377016131000},"page":"8-14","source":"Crossref","is-referenced-by-count":19,"title":["The cellient automated cell block system is useful in the differential diagnosis of atypical glandular cells in Papanicolaou tests"],"prefix":"10.1002","volume":"122","author":[{"given":"Wei","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April Y.","family":"Hou","sequence":"additional","affiliation":[{"name":"Brandeis University Waltham Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical Center Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1992","article-title":"The 2001 Bethesda System terminology","volume":"68","author":"Apgar BS","year":"2003","journal-title":"Am Fam Physician."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-1224-BIARRP"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333970"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/101.6.708"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000218705.87329.4a"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.grf.0000151572.99437.a5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.050"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182883a34"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2008.09.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001025)90:5<265::AID-CNCR1>3.0.CO;2-Q"},{"volume-title":"The Art and Science of Cytopathology","year":"1996","author":"DeMay RM","key":"e_1_2_7_13_1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331830"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22577"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/PLMI.S37555"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20846"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20630"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.3385"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/107.3.299"},{"key":"e_1_2_7_21_1","first-page":"397","article-title":"The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri and related lesions. 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