{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:39:03Z","timestamp":1760315943025,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T00:00:00Z","timestamp":1377475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Pap test (PT) interpretations of low\u2010grade squamous intraepithelial lesion (LSIL), cannot exclude high\u2010grade squamous intraepithelial lesion (HSIL), or LSIL\u2010H, are used in many laboratories; however monitoring its usage for quality assurance purposes is understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>PTs from 2005 to 2010 were collected, and yearly frequencies of LSIL, HSIL, LSIL\u2010H, and atypical squamous cells, cannot exclude HSIL (ASC\u2010H) as a function of total PTs and total squamous intraepithelial lesions (SILs) were calculated. Two\u2010year risk of cervical intraepithelial neoplasia 2 (CIN2) or worse (CIN2+) and CIN 3 or worse (CIN3+) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 352,220 PTs were identified including 17,301 abnormal PTs. LSIL\u2010H usage increased from 2005 to 2010 (from 0.28% of total PTs in 2005 to 0.61% in 2010, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01; from 5.8% of total SILs in 2005 to 12% in 2010, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). HSIL usage decreased significantly from 2005 to 2010 (from 0.7% of total PTs in 2005 to 0.48% in 2010, <jats:italic>P<\/jats:italic>\u2009=\u2009.048; from 14.5% of total SILs in 2005 to 9.5% in 2010, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Usage of LSIL and ASC\u2010H did not change. Two\u2010year risk of CIN2+ and CIN3+ for HSIL increased significantly from 2005 to 2010 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Two\u2010year risk of CIN2+ and CIN3+ for LSIL\u2010H did not change significantly from 2005 to 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The frequency of LSIL\u2010H interpretations is significantly increasing at our institution, with a significant decrease in HSIL interpretations over the same period. Two\u2010year risk of CIN2+ and CIN3+ for HSIL increased significantly as usage of LSIL\u2010H increased and that of HSIL decreased. Laboratories using LSIL\u2010H may benefit from monitoring its frequency to ensure its appropriate use. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2014;122:123\u20137<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21346","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T15:02:44Z","timestamp":1377529364000},"page":"123-127","source":"Crossref","is-referenced-by-count":7,"title":["Evidence for increasing usage of low\u2010grade squamous intraepithelial lesion, cannot exclude high\u2010grade squamous intraepithelial lesion (LSIL\u2010H) Pap test interpretations"],"prefix":"10.1002","volume":"122","author":[{"given":"Vighnesh","family":"Walavalkar","sequence":"first","affiliation":[{"name":"Department of Pathology Division of Cytopathology University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Tommet","sequence":"additional","affiliation":[{"name":"Department of Pathology Division of Cytopathology University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pathology Division of Cytopathology University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Division of Cytopathology University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra M.","family":"Papa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Pathology Division of Cytopathology University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200010)23:4<245::AID-DC6>3.0.CO;2-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11721"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22169"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/QRDNMWWAKJQTVJGF"},{"key":"e_1_2_7_7_1","first-page":"46","article-title":"LSIL\/ASC\u2010H (LSIL\u2010H) in cervicovaginal smear: histopathological outcomes and clinical significance","volume":"27","author":"Kaygusuz EI","year":"2011","journal-title":"Turk Patoloji Derg"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.12.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23984"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-4-7"},{"key":"e_1_2_7_12_1","first-page":"462","article-title":"Reporting of \u201cLSIL with ASC\u2010H\u201d on cervicovaginal smears: is it a valid category to predict cases with HSIL follow\u2010up?","volume":"25","author":"Kir G","year":"2004","journal-title":"Eur J Gynaecol 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