{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:46:55Z","timestamp":1791388015856,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>There is a paucity of data on the effect of vaginal lubricants on specimen adequacy in the era of liquid\u2010based Papanicolaou (Pap) tests. Current manufacturer recommendations advise against the use of lubricants, especially those that contain carbomers or carbopol polymers. There is, however, no conclusive evidence to support this recommendation. Moreover, the data that does exist is conflicting.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Retrospective review was performed of all liquid\u2010based Pap tests collected between January 2010 and March 2012 by the Gynecologic Oncology division at a single hospital. Specimen adequacy was compared for vaginal and cervical specimens that were collected with and without a lubricant. Results were also compared for specimens collected with lubricants that did or did not contain carbomers.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>There was no significant difference in specimen adequacy for cervical or vaginal Pap test specimens collected with a water\u2010soluble lubricant not containing carbomers, compared to those collected without a lubricant. There was, however, a significantly higher rate of insufficient specimens when a water\u2010soluble lubricant containing carbomers was used. This difference was most pronounced for vaginal Pap tests (26.9% versus 1.2%, OR\u2009=\u200930.3, 95% CI\u2009=\u200916.6\u201055.1, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Lubricants containing carbomers should be avoided when collecting liquid\u2010based Pap tests because they can significantly decrease specimen adequacy. Lubricants that do not contain these substances do not significantly affect specimen adequacy. If there is an unusual increase in unsatisfactory Pap tests, the cytology laboratory should notify clinicians and work with them to determine the cause. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2014;122:221\u2013226<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21369","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T10:07:09Z","timestamp":1384855629000},"page":"221-226","source":"Crossref","is-referenced-by-count":16,"title":["Does speculum lubricant affect liquid\u2010based Papanicolaou test adequacy?"],"prefix":"10.1002","volume":"122","author":[{"given":"Stephanie N.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolyn","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology New York\u2010Presbyterian Hospital Weill Cornell Medical Center, New York  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Alperstein","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine New York\u2010Presbyterian Hospital Weill Cornell Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Hoda","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine New York\u2010Presbyterian Hospital Weill Cornell Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Holcomb","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology New York\u2010Presbyterian Hospital Weill Cornell Medical Center, New York  New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"US Food and Drug Administration.May 1996 PMA Approvals.http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf\/p950039.pdf. Accessed November 14 2013."},{"issue":"1","key":"e_1_2_7_3_1","first-page":"S2","article-title":"The impact of liquid\u2010based cytology in decreasing the incidence of cervical cancer","volume":"4","author":"Gibb RK","year":"2011","journal-title":"Rev Obstet Gynecol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20599"},{"key":"e_1_2_7_5_1","unstructured":"US Department of Health and Human Services.Health United States 2011. Table 91.http:\/\/www.cdc.gov\/nchs\/data\/hus\/hus11.pdf. Accessed February 14 2013."},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5858\/134.3.331","article-title":"Practices of participants in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology, 2006","volume":"134","author":"Eversole GM","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22904"},{"key":"e_1_2_7_8_1","unstructured":"Hologic Inc.Lubricant use during Pap sample collection.http:\/\/www.thinprep.com\/pdfs\/colleague_letter.pdf. Accessed February 14 2013."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182426275"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.153.10.1046"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2004.11.021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02348-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02168-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2005.01.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000192512.03576.da"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2007.00525.x"},{"key":"e_1_2_7_17_1","unstructured":"Hologic Inc.ThinPrep operator's manual. Boxborough MA;1997."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2042-8"},{"key":"e_1_2_7_19_1","unstructured":"Department of Health and Human Services.510K Summary.www.accessdata.fda.gov\/cdrh_docs\/pdf9\/K092488.pdf. Accessed September 15 2012."},{"key":"e_1_2_7_20_1","unstructured":"Surgilube Material Safety Data Sheet.www.surgilube.com\/pdfs\/surgi\u2010msds.pdf. Accessed September 15 2012."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-7-11-749"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2011.02.100086"},{"key":"e_1_2_7_23_1","unstructured":"Cyctyc Inc.Letter regarding lubricant use during Pap test collection for the ThinPrep\u00aePap.http:\/\/www.mc.vanderbilt.edu\/root\/pdfs\/vpls\/thinprep.pdf. 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