{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:18:23Z","timestamp":1790050703685,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>It has been demonstrated that axillary ultrasound\u2010guided fine\u2010needle aspiration (US\u2010FNA) has excellent positive predictive value for the axillary lymph node status of patients with breast cancer before surgery or neoadjuvant therapy and, thus, can obviate the need for sentinel lymph node biopsy in FNA\u2010positive patients. However, US\u2010FNA has only moderate sensitivity, in part because of the collection of nondiagnostic or equivocal specimens. Rapid on\u2010site evaluation for adequacy (ROSE) can improve definitive diagnosis rates but has not been well characterized in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>One hundred thirty\u2010three patients with breast carcinoma were identified who underwent 136 US\u2010FNAs of axillary lymph nodes, all with ROSE, and the results were correlated with the diagnosis on a subsequent surgical procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The adequacy rate was 95.6% (130 of 136 FNAs), and a definitive diagnosis was made in 91.2% (124 of 136 FNAs). Among definite diagnoses, sensitivity was 75%, specificity was 100%, the positive predictive value was 100%, and the negative predictive value was 79%. Sources of false\u2010negative and potential false\u2010positive diagnoses were evaluated among these cases and in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Small metastasis size is the most common cause of false\u2010negative results, whereas interpretation errors by pathologists are quite rare. ROSE appears to improve adequacy and definitive diagnosis rates and, thus, can more accurately triage patients to appropriate care. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2014;122:282\u2013291<\/jats:bold>. \u00a9 <jats:italic>2013 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21384","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T11:38:42Z","timestamp":1387366722000},"page":"282-291","source":"Crossref","is-referenced-by-count":32,"title":["Performance characteristics of ultrasound\u2010guided fine\u2010needle aspiration of axillary lymph nodes for metastatic breast cancer employing rapid on\u2010site evaluation of adequacy: Analysis of 136 cases and review of the literature"],"prefix":"10.1002","volume":"122","author":[{"given":"Adele D.","family":"Fung","sequence":"first","affiliation":[{"name":"Department of Pathology University of Maryland School of Medicine and University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Maryland School of Medicine and University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Campassi","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Maryland School of Medicine and University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga B.","family":"Ioffe","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Maryland School of Medicine and University of Maryland Medical Center Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul 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