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In conjunction with endoscopic ultrasound\u2010guided fine\u2010needle aspiration (EUS\u2010FNA), a nearly complete mediastinal evaluation can be performed in a minimally invasive fashion. This strategy results in improved lymph node staging, markedly reduced need for mediastinoscopy, and fewer futile thoracotomies compared with a traditional surgical staging procedure. The procedure is cost effective and provides excellent cytologic specimens that have proven well suited for ancillary testing, such as immunohistochemistry and tumor genotyping. EBUS\u2010TBNA, initially used as a tool to sample the lymph nodes adjacent to the airway walls, has now become instrumental in sampling lesions in the mediastinum, hilum, and lung parenchyma, where previously more than 1 procedure would have been necessary. Looking forward, expanded use of this procedure is likely to revolutionize the access to cytology\u2010proven staging and restaging of lung cancer and other thoracic malignancies in a minimally invasive fashion. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2014;122:561\u2013576.<\/jats:bold> \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cncy.21431","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T17:24:46Z","timestamp":1398273886000},"page":"561-576","source":"Crossref","is-referenced-by-count":86,"title":["Endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA): An overview and update for the cytopathologist"],"prefix":"10.1002","volume":"122","author":[{"given":"Paul A.","family":"VanderLaan","sequence":"first","affiliation":[{"name":"Department of Pathology, Division of Cytopathology, Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Cytopathology, Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Majid","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Folch","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"e_1_2_4_2_1","volume-title":"Cancer Facts & Figures","author":"American Cancer Society","year":"2013"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11898"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.089391"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2012.05.001"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574887111308010009"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2009.00722.x"},{"key":"e_1_2_4_8_1","first-page":"497","article-title":"Mediastinal puncture thru the tracheal carina","volume":"63","author":"Schieppati E","year":"1949","journal-title":"Rev Assoc Med Argent"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.5.571"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.041525"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.7.565"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(97)00112-9"},{"key":"e_1_2_4_13_1","first-page":"179","volume-title":"Atlas of Chest Sonography","author":"Herth F","year":"2003"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v4.i12.532"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.10.021"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1362"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1119000"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200411-1560OC"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2100"},{"key":"e_1_2_4_20_1","volume-title":"International Union against Cancer. 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