{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:14:22Z","timestamp":1790374462099,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Secondary neoplasms of the thyroid gland (SNTGs) are uncommon, and it is important to recognize them in thyroid fine\u2010needle aspiration biopsy (FNAB).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors report a cohort of 62 SNTGs from 7 institutions in the United States and Europe. Patients were identified retrospectively by searching through medical records of the respective institutions. All initial diagnoses were rendered by FNAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>SNTGs represented 0.16% of all thyroid FNABs and were more frequent among women (ratio of women to men, 1.2:1.0). The mean patient age was of 59 years (range, 7\u201084 years), the mean tumor size was 3 cm (range, 0.9\u20107 cm), and the mean interval from diagnosis of the primary tumor was 45 months (range, 0\u2010156 months). Eighty\u2010seven percent of SNTGs were diagnosed as malignant by FNAB, and there was a specific SNTG diagnosis in 93% of patients. Immunocytochemistry and flow cytometry, which were used in 30% of patients, were useful ancillary studies. Adenocarcinomas (n\u2009=\u200923; 37%) and squamous cell carcinomas (SCCs) (n\u2009=\u200922; 35.5%) represented the majority of SNTGs, followed by lymphoma (n\u2009=\u20095; 8%), melanoma (n\u2009=\u20095; 8%), adenoid cystic carcinoma (n\u2009=\u20093; 5%), and various sarcomas (n\u2009=\u20093; 5%). Adenocarcinomas originated from the kidney (n\u2009=\u20099; 39%), lung (n\u2009=\u20096; 26%), breast (n\u2009=\u20095; 22%), and colon (n\u2009=\u20093; 13%). SCCs originated mostly from the head and neck (n\u2009=\u200913; 59%), followed by lung (n\u2009=\u20093; 13%), esophagus (n\u2009=\u20093; 14%), and unknown primary sites (n\u2009=\u20093; 14%).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Adenocarcinomas from the kidney, lung, breast, and colon along with SCCs represent the majority of SNTGs. The current results indicate that FNAB is a sensitive and accurate method for diagnosing SNTG; however, diagnostic difficulties can occur. Knowledge of clinical history and the judicious application of ancillary studies can increase the sensitivity and accuracy of FNAB for detecting SNTGs. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2015;123:19\u201329<\/jats:bold>. \u00a9 <jats:italic>2014 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21494","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T10:38:11Z","timestamp":1415097491000},"page":"19-29","source":"Crossref","is-referenced-by-count":81,"title":["Fine\u2010needle aspiration biopsy of secondary neoplasms of the thyroid gland: A multi\u2010institutional study of 62 cases"],"prefix":"10.1002","volume":"123","author":[{"given":"Marc","family":"Pusztaszeri","sequence":"first","affiliation":[{"name":"Department of Pathology Geneva University Hospital Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Temple University School of Medicine Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund S.","family":"Cibas","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste N.","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Pathology Virginia Commonwealth University Health Systems Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"Institute of Pathology Locarno Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal K.","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Pathology State University of New York Upstate Medical University Syracuse New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Faquin","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts"},{"name":"Department of Pathology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02773.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<574::AID-CNCR21>3.0.CO;2-#"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-006-0081-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02206.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.03.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24416"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840130306"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1001\/archinte.1987.00370020129049","article-title":"Fine\u2010needle aspiration. 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