{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:09:21Z","timestamp":1784768961366,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The solid variant of papillary thyroid carcinoma (SVPTC) comprises approximately 3% of thyroid cancers, and there are conflicting reports about its behavior in the literature. The cytology of SVPTC is limited to 3 single case reports, a review article, and a monograph. We present the first cytologic study of SVPTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Fine\u2010needle aspiration smears obtained with ultrasound guidance from 13 patients with histologically pure SVPTC were reviewed, and the cytologic features recorded. Ultrasound images were retrieved from radiology and were correlated with low\u2010power histology images. Intratumor vascularity on Doppler imaging was correlated with cellularity in cytology samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Three cytomorphologic patterns of SVPTC were identified: cohesive, syncytial\u2010type tissue fragments; microfollicles\/trabeculae; and dyshesive single cells. All 3 SVPTCs in the first group were encapsulated without invasion. Two of 6 SVPTCs in the second group had a single lymph node metastasis; 4 were encapsulated, and 2 had pushing borders. Ultrasound images in the first and second SVPTC groups were similar, with the majority revealing a well defined, solid nodule with minimal intranodular vascularity. All 4 SVPTCs in the third group had infiltrative borders; and, with the exception of one 0.8\u2010cm tumor, all had multiple lymph node metastases. Ultrasound in the third group revealed irregular borders. <jats:italic>RET\/PTC1<\/jats:italic> and <jats:italic>RET\/PTC3<\/jats:italic> mutations were found in 2 cases of the third group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>SVPTCs are heterogeneous tumors. The cohesive, syncytial tissue\u2010fragment pattern can be recognized as SVPTC in smears and is associated with encapsulation and indolent behavior. The microfollicular\/trabecular pattern is indistinguishable from that of the follicular variant of papillary thyroid carcinoma and has intermediate behavior. The dyshesive single\u2010cell pattern correlates with infiltrative tumor growth and may not be unique to SVPTC. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2015;123:71\u201381.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21504","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T13:48:41Z","timestamp":1420724921000},"page":"71-81","source":"Crossref","is-referenced-by-count":38,"title":["Fine\u2010needle aspiration cytology of the solid variant of papillary thyroid carcinoma: A study of 13 cases with clinical, histologic, and ultrasound correlations"],"prefix":"10.1002","volume":"123","author":[{"given":"Tamar A.","family":"Giorgadze","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Medical College of Cornell University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Medical College of Cornell University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace C. H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Weill Medical College of Cornell University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850215)55:4<805::AID-CNCR2820550419>3.0.CO;2-Z"},{"key":"e_1_2_7_3_1","volume-title":"Tumors of the Thyroid Gland. 3rd Series, Fascicle 5","author":"Rosai J","year":"1992"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000415)88:8<1902::AID-CNCR20>3.0.CO;2-Y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200112000-00002"},{"key":"e_1_2_7_6_1","first-page":"1690","article-title":"Distinct pattern of ret oncogene rearrangements in morphological variants of radiation\u2010induced and sporadic thyroid papillary carcinomas in children","volume":"57","author":"Nikiforov YE","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_7_7_1","first-page":"408","article-title":"Aggressive behaviour of solid arrangement pattern in differentiated papillary carcinoma of thyroid","volume":"51","author":"Basu S","year":"2003","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20044"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.129"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21494"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-010-0236-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-009-9073-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-5-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-3919.106707"},{"key":"e_1_2_7_15_1","first-page":"55","article-title":"Ultrafast Papanicolaou stain: an alternative preparation for fine\u2010needle aspiration cytology","volume":"39","author":"Yang GCH","year":"1995","journal-title":"Acta Cytol"},{"key":"e_1_2_7_16_1","first-page":"5","article-title":"The National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference: a summation [serial online]","author":"Baloch ZW","year":"2008","journal-title":"Cytojournal"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.12307"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21417"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139135504"},{"key":"e_1_2_7_20_1","first-page":"552","article-title":"Clear nuclei of papillary thyroid carcinoma conspicuous in fine\u2010needle aspiration and intraoperative smears processed by ultrafast Papanicolaou stain","volume":"10","author":"Yang GC","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342986"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.2.216"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980825)84:4<235::AID-CNCR9>3.0.CO;2-L"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5858\/2006-130-148-IAOMIT","article-title":"College of American Pathologists Cytopathology Committee. 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