{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:07:42Z","timestamp":1761293262671,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cytopathology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The current management strategy for women with low\u2010grade squamous intraepithelial lesions (LSILs) is inefficient and expensive because of the inability to identify patients at high risk for disease progression. The current study was designed to determine the genotypic patterns of human papillomavirus (HPV) associated with the persistence and progression of cervical lesions in women with an initial interpretation of LSIL.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>One hundred sixty\u2010seven women with LSIL on Papanicolaou tests collected between December 1, 2009 and March 30, 2011 were studied. HPV DNA was extracted from residual SurePath specimens, genotypes were determined with a DNA microarray containing 40 HPV genotype probes, and microarray data were confirmed by sequencing. Follow\u2010up Papanicolaou tests and\/or biopsies were performed within a 20\u2010 to 46\u2010month period after the initial diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Ninety\u2010seven of the 167 cases with follow\u2010up results were included in the study. Compared with the women with a regressed cervical lesion, those with a persistent cervical lesion (PCL) were significantly more commonly infected with high\u2010risk human papillomavirus (HR\u2010HPV) genotypes (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and particularly with non\u201016\/18 HR\u2010HPV genotypes (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The PCL group also had a significantly higher average number of HR\u2010HPV genotypes and non\u201016\/18 HPV genotypes per specimen (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Infection with HPV\u201016\/18 genotypes was not significantly associated with the persistence or progression of cervical lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Infection with non\u201016\/18 HR\u2010HPV genotypes but not with HPV\u201016\/18 genotypes was a strong predictor of the persistence and progression of cervical disease upon follow\u2010up. Genotyping solely for HPV\u201016\/18 would miss the majority of patients with LSIL who progress to high\u2010grade squamous intraepithelial lesions. Pooled HR\u2010HPV tests provide a better predictive value than HPV\u201016\/18 genotyping alone in guiding the clinical management of patients with LSIL. <jats:bold><jats:italic>Cancer (Cancer Cytopathol)<\/jats:italic> 2015;123:435\u201042.<\/jats:bold> \u00a9 <jats:italic>2015 American Cancer Society<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cncy.21549","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T14:49:00Z","timestamp":1429714140000},"page":"435-442","source":"Crossref","is-referenced-by-count":13,"title":["Non\u201016\/18 high\u2010risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL"],"prefix":"10.1002","volume":"123","author":[{"given":"Yasmin A.","family":"Lyons","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Houston Methodist Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna A.","family":"Kamat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Houston Methodist Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina R.","family":"Mody","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary R.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Hobday","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Houston Methodist Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001204000210"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1097\/AOG.0b013e318277c92a","article-title":"Committee on Practice Bulletins\u2013Gynecology ACOG practice bulletin number 131: screening for cervical cancer","volume":"120","author":"2","year":"2012","journal-title":"Obstet Gynecol."},{"key":"e_1_2_7_4_1","unstructured":"Centers for Disease Control and Prevention. 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